Literature DB >> 7768623

In vitro evaluation of the role of humoral immunity against Bartonella henselae.

M C Rodriguez-Barradas1, J C Bandres, R J Hamill, J Trial, J E Clarridge, R E Baughn, R D Rossen.   

Abstract

The contribution of humoral immunity against Bartonella henselae was evaluated by examining the in vitro bactericidal activity of sera and the ability of these microorganisms to activate complement and stimulate phagocytosis and an oxidative burst in polymorphonuclear leukocytes. The organism was killed by complement-mediated cytolysis. Complement activation preferentially proceeded by the alternative pathway. The presence of specific antibodies did not increase the serum bactericidal activity or complement activation. However, phagocytosis and the subsequent production of oxygen radicals, evaluated by flow cytometry, were significantly enhanced in the presence of bacteria previously opsonized with immune sera.

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Year:  1995        PMID: 7768623      PMCID: PMC173313          DOI: 10.1128/iai.63.6.2367-2370.1995

Source DB:  PubMed          Journal:  Infect Immun        ISSN: 0019-9567            Impact factor:   3.441


  20 in total

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Review 5.  The structure and function of vertebrate mannose lectin-like proteins.

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  11 in total

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Review 3.  Bartonella spp. as emerging human pathogens.

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Review 4.  Intruders below the radar: molecular pathogenesis of Bartonella spp.

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8.  Bartonella henselae invasion of feline erythrocytes in vitro.

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9.  Identification of Bartonella-specific immunodominant antigens recognized by the feline humoral immune system.

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10.  Schizophrenia and Bartonella spp. Infection: A Pilot Case-Control Study.

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