Literature DB >> 7768545

Interleukin-4 inhibits the expression of tumour necrosis factors alpha and beta, interleukins-1 beta and -6 and interferon-gamma.

J D Lee1, K Rhoades, J S Economou.   

Abstract

T cell-derived IL-4 inhibits the expression of several inflammatory cytokine genes. In this study, IL-4 downregulated TNF-alpha and -beta, IL-1 beta IL-6 and IFN-gamma steady-state mRNA and protein production by blood leukocytes. In a detailed kinetic analysis, cytokine mRNA levels were significantly decreased in the presence of IL-4, suggesting an early and prolonged downregulatory effect. These findings support the general thesis that IL-4 is an important regulator of the inflammatory immune response.

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Year:  1995        PMID： 7768545     DOI： 10.1038/icb.1995.9

Source DB:  PubMed          Journal:  Immunol Cell Biol        ISSN： 0818-9641            Impact factor:   5.126


  9 in total

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Authors:  J H Curfs; J F Meis; J A Hoogkamp-Korstanje
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2.  Purification of placenta-eluted gamma globulins and their strong effect against graft-versus-host reactions in vitro and in vivo.

Authors:  Fang Liu; Dao-Pei Lu
Journal:  Int J Hematol       Date:  2005-08       Impact factor: 2.490

3.  Interindividual variations in cytokine levels following cardiopulmonary bypass.

Authors:  M Misoph; J Babin-Ebell
Journal:  Heart Vessels       Date:  1997       Impact factor: 2.037

4.  Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes.

Authors:  I M Medana; N H Hunt; G Chaudhri
Journal:  Am J Pathol       Date:  1997-04       Impact factor: 4.307

5.  Murine metal-induced systemic autoimmunity: baseline and stimulated cytokine mRNA expression in genetically susceptible and resistant strains.

Authors:  B Häggqvist; P Hultman
Journal:  Clin Exp Immunol       Date:  2001-10       Impact factor: 4.330

6.  Induction of interleukin-4 (IL-4) by legionella pneumophila infection in BALB/c mice and regulation of tumor necrosis factor alpha, IL-6, and IL-1beta.

Authors:  C Newton; S McHugh; R Widen; N Nakachi; T Klein; H Friedman
Journal:  Infect Immun       Date:  2000-09       Impact factor: 3.441

7.  Fluticasone propionate-induced regulation of the balance within macrophage subpopulations.

Authors:  V J Tormey; S Bernard; K Ivory; C M Burke; L W Poulter
Journal:  Clin Exp Immunol       Date:  2000-01       Impact factor: 4.330

8.  Differential expression of cytokine transcripts in human epithelial ovarian carcinoma by solid tumour specimens, peritoneal exudate cells containing tumour, tumour-infiltrating lymphocyte (TIL)-derived T cell lines and established tumour cell lines.

Authors:  M A Nash; R Lenzi; C L Edwards; J J Kavanagh; A P Kudelka; C F Verschraegen; C D Platsoucas; R S Freedman
Journal:  Clin Exp Immunol       Date:  1998-05       Impact factor: 4.330

9.  Effects of deviating the Th2-response in murine mercury-induced autoimmunity towards a Th1-response.

Authors:  B Häggqvist; P Hultman
Journal:  Clin Exp Immunol       Date:  2003-11       Impact factor: 4.330
  9 in total

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