Literature DB >> 7767981

Induction of minisatellite DNA rearrangements by genotoxic carcinogens in mouse liver tumors.

B J Ledwith1, D J Joslyn, P Troilo, K R Leander, J H Clair, K A Soper, S Manam, S Prahalada, M J van Zwieten, W W Nichols.   

Abstract

We investigated whether somatic rearrangements in minisatellite DNA are more frequent in chemically induced mouse liver tumors than they are in spontaneous tumors. CD-1 mouse liver tumors were induced by either a single dose or 15 consecutive daily doses of 7,12-dimethylbenz[alpha]anthracene, 4-aminoazobenzene, N-hydroxy-2-acetyl-aminofluorene or diethylnitrosoamine (DEN). Using DNA fingerprinting analysis, we found that the single- and multiple-dose carcinogen treatments caused a 2- to 5-fold higher frequency of minisatellite DNA rearrangements compared with that found in spontaneous tumors--with the exception of single-dose DEN tumors, which showed no increase in rearrangements. Our results suggest that DNA fingerprinting may be a valuable assay for differentiating certain chemically induced tumors from spontaneous tumors.

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Year:  1995        PMID： 7767981     DOI： 10.1093/carcin/16.5.1167

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  5 in total

1.  Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1.

Authors:  Hirokazu Fukuda; Masato Katahira; Naoto Tsuchiya; Yoshiaki Enokizono; Takashi Sugimura; Minako Nagao; Hitoshi Nakagama
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-16       Impact factor: 11.205

2.  Multilocus DNA fingerprinting reveals high rate of heritable genetic mutation in herring gulls nesting in an industrialized urban site.

Authors:  C L Yauk; J S Quinn
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

3.  Minisatellite instability in severe combined immunodeficiency mouse cells.

Authors:  H Imai; H Nakagama; K Komatsu; T Shiraishi; H Fukuda; T Sugimura; M Nagao
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

4.  Induction of minisatellite mutation in NIH 3T3 cells by treatment with the tumor promoter okadaic acid.

Authors:  H Nakagama; S Kaneko; H Shima; H Inamori; H Fukuda; R Kominami; T Sugimura; M Nagao
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-30       Impact factor: 11.205

5.  Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells.

Authors:  F Okada; K Nakai; T Kobayashi; T Shibata; S Tagami; Y Kawakami; T Kitazawa; R Kominami; S Yoshimura; K Suzuki; N Taniguchi; O Inanami; M Kuwabara; H Kishida; D Nakae; Y Konishi; T Moriuchi; M Hosokawa
Journal:  Br J Cancer       Date:  1999-02       Impact factor: 7.640
  5 in total

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