Literature DB >> 776647

The effects of tryptophol on immune responses and it implications toward trypanosome-induced immunosuppression.

S B Ackerman, J R Seed.   

Abstract

Daily administration of tryptophol to laboratory rodents resulted in significantly depressed antibody production of heterologous red blood cell challenge, did not alter cellular-mediated responses to oxazalone. These results suggest that trypanosome-produced tryptophol may account for the immunodepression observed during trypanosomiasis.

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Year:  1976        PMID： 776647     DOI： 10.1007/bf01990212

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  9 in total

1.  Chromatographic evidence for the synthesis of possible sleep-mediators in Trypanosoma brucei gambiense.

Authors:  H H Stibbs; J R Seed
Journal:  Experientia       Date:  1973-12

2.  The response of mice infected with T. brucei to the administration of sheep erythrocytes.

Authors:  P K Murray; G M Urquhart; M Murray; F W Jennings
Journal:  Trans R Soc Trop Med Hyg       Date:  1973       Impact factor: 2.184

3.  Immunosuppression in Gambian trypanosomiasis.

Authors:  B M Greenwood; H C Whittle; D H Molyneux
Journal:  Trans R Soc Trop Med Hyg       Date:  1973       Impact factor: 2.184

4.  Immunosuppression in Trypanosoma brucei infections in rats and mice.

Authors:  G M Urquhart; M Murray; P K Murray; F W Jennings; E Bate
Journal:  Trans R Soc Trop Med Hyg       Date:  1973       Impact factor: 2.184

5.  Immunosuppression during trypanosomiasis.

Authors:  L G Goodwin; D G Green; M W Guy; A Voller
Journal:  Br J Exp Pathol       Date:  1972-02

6.  The role of the hypothalamo-pituitary system in the mechanism of action of reserpine and 5-hydroxytryptophan on antibody production.

Authors:  L V Devoino; O F Eremina; R Y Ilyutchenok
Journal:  Neuropharmacology       Date:  1970-01       Impact factor: 5.250

7.  Influence of some drugs on the immune response. I. The effect of 5-hydroxytryptophan, iproniazid and reserpine on primary and secondary immune responses.

Authors:  L V Devoino; L S Korovina; R Y Ilyutchenok
Journal:  Eur J Pharmacol       Date:  1968-11       Impact factor: 4.432

8.  Influence of some drugs on the immune response. II. Effects of serotonin, 5-hydroxytryptophan, reserpine and iproniazid on delayed hypersensitivity.

Authors:  L V Devoino; R Y Ilyutchenok
Journal:  Eur J Pharmacol       Date:  1968-11       Impact factor: 4.432

9.  Effects of Trypanosoma brucei gambiense infections in Microtus montanus on susceptibility to Ehrlich's tumors.

Authors:  S B Ackerman; J R Seed
Journal:  Infect Immun       Date:  1976-02       Impact factor: 3.441
  9 in total
  3 in total

Review 1.  Biologically active products from African Trypanosomes.

Authors:  I Tizard; K H Nielsen; J R Seed; J E Hall
Journal:  Microbiol Rev       Date:  1978-12

2.  Rapid distribution of tryptophol (3-indole ethanol) to the brain and other tissues.

Authors:  E M Cornford; W D Bocash; L D Braun; P D Crane; W H Oldendorf; A J MacInnis
Journal:  J Clin Invest       Date:  1979-06       Impact factor: 14.808

3.  Immunosuppression in the definitive and intermediate hosts of the human parasite Schistosoma mansoni by release of immunoactive neuropeptides.

Authors:  O Duvaux-Miret; G B Stefano; E M Smith; C Dissous; A Capron
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-15       Impact factor: 11.205
  3 in total

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