Literature DB >> 7766222

Biomedical and biotechnological applications of PEG- and PM-modified proteins.

Y Inada1, M Furukawa, H Sasaki, Y Kodera, M Hiroto, H Nishimura, A Matsushima.   

Abstract

Chemical modification of proteins and other bioactive molecules with polyethylene glycol (PEG) or its derivatives (PM) can be used to tailor molecular properties to particular applications, eliminating disadvantageous properties or conferring new molecular functions. Complexes of therapeutic proteins and PEG or PM show reduced immunoreactivity, prolonged clearance times and improved biostability. Modification with PEG can also increase the solubility and activity of enzymes in organic solvents, thus extending their potential for application in organic syntheses and biotransformation processes.

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Year:  1995        PMID： 7766222     DOI： 10.1016/S0167-7799(00)88912-X

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  18 in total

1.  Carboxyalkylated histidine is a pH-dependent product of pegylation with SC-PEG.

Authors:  D C Wylie; M Voloch; S Lee; Y H Liu; S Cannon-Carlson; C Cutler; B Pramanik
Journal:  Pharm Res       Date:  2001-09       Impact factor: 4.200

2.  "Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung.

Authors:  M A Croyle; N Chirmule; Y Zhang; J M Wilson
Journal:  J Virol       Date:  2001-05       Impact factor: 5.103

3.  Real-time observation of protein aggregates in pharmaceutical formulations using liquid cell electron microscopy.

Authors:  Lynn M DiMemmo; A Cameron Varano; Jonathan Haulenbeek; Yanping Liang; Kaya Patel; Madeline J Dukes; Songyan Zheng; Mario Hubert; Steven P Piccoli; Deborah F Kelly
Journal:  Lab Chip       Date:  2017-01-17       Impact factor: 6.799

4.  Treatment with peginterferon versus interferon in Chinese patients with chronic hepatitis C.

Authors:  S Zhao; E Liu; K Wei; Y Wang; Y Li; B Huang; Y Chen; P Yang
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2010-09-09       Impact factor: 3.267

5.  Tailoring structure-function properties of L-asparaginase: engineering resistance to trypsin cleavage.

Authors:  Georgia A Kotzia; Katerina Lappa; Nikolaos E Labrou
Journal:  Biochem J       Date:  2007-06-01       Impact factor: 3.857

6.  Characterization and stability of N-terminally PEGylated rhG-CSF.

Authors:  O B Kinstler; D N Brems; S L Lauren; A G Paige; J B Hamburger; M J Treuheit
Journal:  Pharm Res       Date:  1996-07       Impact factor: 4.200

7.  Formulation of PEG-based hydrogels affects tissue-engineered cartilage construct characteristics.

Authors:  S L Riley; S Dutt; R De La Torre; A C Chen; R L Sah; A Ratcliffe
Journal:  J Mater Sci Mater Med       Date:  2001 Oct-Dec       Impact factor: 3.896

8.  Enzymatic activity and thermal stability of PEG-alpha-chymotrypsin conjugates.

Authors:  José A Rodríguez-Martínez; Izarys Rivera-Rivera; Ricardo J Solá; Kai Griebenow
Journal:  Biotechnol Lett       Date:  2009-02-18       Impact factor: 2.461

9.  Probing the mechanism for hydrogel-based stasis induction in human pluripotent stem cells: is the chemical functionality of the hydrogel important?

Authors:  M Sponchioni; C T O'Brien; C Borchers; E Wang; M N Rivolta; N J W Penfold; I Canton; S P Armes
Journal:  Chem Sci       Date:  2019-11-11       Impact factor: 9.825

10.  Actively-targeted LTVSPWY peptide-modified magnetic nanoparticles for tumor imaging.

Authors:  Li-Yong Jie; Li-Li Cai; Le-Jian Wang; Xiao-Ying Ying; Ri-Sheng Yu; Min-Ming Zhang; Yong-Zhong Du
Journal:  Int J Nanomedicine       Date:  2012-07-24
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