Literature DB >> 7766002

Cytotoxic clerodane diterpenes from Polyalthia barnesii.

X Ma1, I S Lee, H B Chai, K Zaw, N R Farnsworth, D D Soejarto, G A Cordell, J M Pezzuto, A D Kinghorn.   

Abstract

Three cytotoxic clerodane diterpenes were purified from an ethyl acetate-soluble extract of the stem bark of Polyalthia barnesii, namely, 16 alpha-hydroxycleroda-3,13(14)Z-dien-15,16-olide, a known compound, and two novel compounds, 3 beta, 16 alpha-dihydroxycleroda-4(18),13(14)Z-dien-15,16-olide and 4 beta, 16 alpha-dihydroxyclerod-13(14)Z-en-15,16-olide. These compounds were found to exhibit broad cytotoxicity against a panel of human cancer cell lines.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7766002     DOI： 10.1016/s0031-9422(00)89587-4

Source DB:  PubMed          Journal:  Phytochemistry        ISSN： 0031-9422            Impact factor:   4.072


  4 in total

Review 1.  Clerodane diterpenes: sources, structures, and biological activities.

Authors:  Rongtao Li; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2016-07-18       Impact factor: 13.423

2.  Cytotoxic constituents from the fruiting branches of Callicarpa americana collected in southern Florida.

Authors:  William P Jones; Tatiana Lobo-Echeverri; Qiuwen Mi; Hee-Byung Chai; Djaja D Soejarto; Geoffrey A Cordell; Steven M Swanson; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2007-02-06       Impact factor: 4.050

3.  Potential anti-hepatocellular carcinoma properties and mechanisms of action of clerodane diterpenes isolated from Polyalthia longifolia seeds.

Authors:  Vinay Bharadwaj Tatipamula; Chandi Vishala Thonangi; Tikam Chand Dakal; Girija Sastry Vedula; Bhanupriya Dhabhai; Haritha Polimati; Annapurna Akula; Ha Thi Nguyen
Journal:  Sci Rep       Date:  2022-06-03       Impact factor: 4.996

4.  Clerodane Diterpenoids from an Edible Plant Justicia insularis: Discovery, Cytotoxicity, and Apoptosis Induction in Human Ovarian Cancer Cells.

Authors:  Idowu E Fadayomi; Okiemute R Johnson-Ajinwo; Elisabete Pires; James McCullagh; Tim D W Claridge; Nicholas R Forsyth; Wen-Wu Li
Journal:  Molecules       Date:  2021-09-30       Impact factor: 4.411
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.