Literature DB >> 7765968

Functional analysis of the promoter of the Saccharomyces cerevisiae multidrug resistance gene YDR1, which encodes a member of the ATP binding cassette (ABC) superfamily.

K Miyahara1, D Hirata, T Miyakawa.   

Abstract

The Saccharomyces cerevisiae gene YDR1/PDR5/STS1, which encodes a member of the ATP binding cassette (ABC) superfamily, is important for cross-resistance to apparently unrelated drugs. The expression of YDR1 is induced by various drugs and heat shock [Hirata et al., Curr. Genet., 26, 285-294 (1994)]. By deletion analysis of the 5'-noncoding region of the YDR1 gene, two drug responsive regions (-604 to -485 and -335 to -275) were identified with fluphenazine and cycloheximide. Three conserved palindrome sequences were found in these regions.

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Year:  1995        PMID： 7765968     DOI： 10.1271/bbb.59.147

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  2 in total

1.  yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae.

Authors:  K Miyahara; D Hirata; T Miyakawa
Journal:  Curr Genet       Date:  1996-01       Impact factor: 3.886

2.  Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata.

Authors:  H Miyazaki; Y Miyazaki; A Geber; T Parkinson; C Hitchcock; D J Falconer; D J Ward; K Marsden; J E Bennett
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191
  2 in total

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