Literature DB >> 7765075

Antigen-induced conformational changes in antibodies: a problem for structural prediction and design.

R L Stanfield1, I A Wilson.   

Abstract

Recent work has shown that large conformational changes in antibodies can accompany antigen binding. These structural changes can alter dramatically the size, shape and charge distribution in the antigen-binding pocket, and may present problems for accurate modeling of antibody structures.

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Year:  1994        PMID： 7765075     DOI： 10.1016/0167-7799(94)90139-2

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  12 in total

1.  Improved affinity of engineered streptavidin for the Strep-tag II peptide is due to a fixed open conformation of the lid-like loop at the binding site.

Authors:  Ingo P Korndörfer; Arne Skerra
Journal:  Protein Sci       Date:  2002-04       Impact factor: 6.725

2.  Polyreactive antigen-binding B (PAB-) cells are widely distributed and the PAB population consists of both B-1+ and B-1- phenotypes.

Authors:  Z-H Zhou; A L Notkins
Journal:  Clin Exp Immunol       Date:  2004-07       Impact factor: 4.330

3.  Antigen-Induced Activation of Antibody Measured by Fluorescence Enhancement of FITC Label at Fc.

Authors:  Genu George; Mandagini Geetha; Padinjaradath S Appukuttan
Journal:  J Fluoresc       Date:  2015-08-11       Impact factor: 2.217

4.  Perturbation of the antigen-binding site and staphylococcal protein A-binding site of IgG before significant changes in global conformation during denaturation: an equilibrium study.

Authors:  X D Wang; J Luo; Z Q Guo; J M Zhou; C L Tsou
Journal:  Biochem J       Date:  1997-08-01       Impact factor: 3.857

5.  Crystal structure of an anti-interleukin-2 monoclonal antibody Fab complexed with an antigenic nonapeptide.

Authors:  P V Afonin; A V Fokin; I N Tsygannik; I Y Mikhailova; L V Onoprienko; I I Mikhaleva; V T Ivanov; T Y Mareeva; V A Nesmeyanov; N Li; W A Pangborn; W L Duax; V Z Pletnev
Journal:  Protein Sci       Date:  2001-08       Impact factor: 6.725

6.  Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon.

Authors:  T J Smith; E S Chase; T J Schmidt; N H Olson; T S Baker
Journal:  Nature       Date:  1996-09-26       Impact factor: 49.962

7.  The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 alphabeta to MHC class I.

Authors:  D A Shore; H Issafras; E Landais; L Teyton; I A Wilson
Journal:  J Mol Biol       Date:  2008-10-07       Impact factor: 5.469

8.  The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3.

Authors:  X Y Pei; P Holliger; A G Murzin; R L Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1997-09-02       Impact factor: 11.205

9.  Promiscuous antibodies characterised by their physico-chemical properties: From sequence to structure and back.

Authors:  Julie M J Laffy; Tihomir Dodev; Jamie A Macpherson; Catherine Townsend; Hui Chun Lu; Deborah Dunn-Walters; Franca Fraternali
Journal:  Prog Biophys Mol Biol       Date:  2016-09-14       Impact factor: 3.667

10.  Characterizing the Diversity of the CDR-H3 Loop Conformational Ensembles in Relationship to Antibody Binding Properties.

Authors:  Monica L Fernández-Quintero; Johannes R Loeffler; Johannes Kraml; Ursula Kahler; Anna S Kamenik; Klaus R Liedl
Journal:  Front Immunol       Date:  2019-01-07       Impact factor: 7.561
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