Literature DB >> 7764842

Inhibition of penicillin biosynthetic enzymes by halogen derivatives of phenylacetic acid.

H Martínez-Blanco1, A Reglero, J M Luengo.   

Abstract

The effect of phenylacetic acid (PAA) and several analogs on the activity of isopenicillin N synthase (IPNS) and acyl-CoA: 6-APA acyltransferase (AT) from Penicillium chrysogenum Wis 54-1255 has been tested. Whereas the substitution on the ring of a hydrogen atom by hydroxy-, methyl- or methoxy- groups did not cause any effect, the presence of halogens (Cl or Br) at positions 3 and/or 4 of PAA strongly inhibited these two enzymes. The replacement of hydrogen atoms by fluorine in certain positions also caused inhibition, but to a lesser extent.

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Year:  1994        PMID： 7764842     DOI： 10.1007/BF01583998

Source DB:  PubMed          Journal:  J Ind Microbiol        ISSN： 0169-4146


  6 in total

1.  IV. Acyl-CoA: 6-APA acyltransferase of Penicillium chrysogenum: studies on substrate specificity using phenylacetyl-CoA variants.

Authors:  J Martín-Villacorta; A Reglero; J M Luengo
Journal:  J Antibiot (Tokyo)       Date:  1989-10       Impact factor: 2.649

2.  Reversible binding of Pi by beef heart mitochondrial adenosine triphosphatase.

Authors:  H S Penefsky
Journal:  J Biol Chem       Date:  1977-05-10       Impact factor: 5.157

3.  Uptake of phenylacetic acid by Penicillium chrysogenum Wis 54-1255: a critical regulatory point in benzylpenicillin biosynthesis.

Authors:  J M Fernández-Cañón; A Reglero; H Martínez-Blanco; J M Luengo
Journal:  J Antibiot (Tokyo)       Date:  1989-09       Impact factor: 2.649

4.  Cell-free conversion of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium.

Authors:  T Konomi; S Herchen; J E Baldwin; M Yoshida; N A Hunt; A L Demain
Journal:  Biochem J       Date:  1979-11-15       Impact factor: 3.857

5.  Enzymatic synthesis of penicillins.

Authors:  M J Alonso; F Bermejo; A Reglero; J M Fernández-Cañón; G González de Buitrago; J M Luengo
Journal:  J Antibiot (Tokyo)       Date:  1988-08       Impact factor: 2.649

6.  Direct enzymatic synthesis of natural penicillins using phenylacetyl-CoA: 6-APA phenylacetyl transferase of Penicillium chrysogenum: minimal and maximal side chain length requirements.

Authors:  J M Luengo; J L Iriso; M J López-Nieto
Journal:  J Antibiot (Tokyo)       Date:  1986-12       Impact factor: 2.649
  6 in total

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