Literature DB >> 7763478

Alzheimer's disease--from cause to cure?

G Vines.   

Abstract

The tools of molecular biology have only been applied to the study of the brain since the early 1980s, but it is already apparent that this approach holds promise for identifying strategies and drugs that are able to modify the activity and function of particular neural pathways. One of the greatest prizes--both for society and commercially--will be the discovery of a safe and effective drug to treat Alzheimer's disease.

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Year:  1993        PMID： 7763478     DOI： 10.1016/0167-7799(93)90122-P

Source DB:  PubMed          Journal:  Trends Biotechnol        ISSN： 0167-7799            Impact factor:   19.536


  4 in total

1.  Immunization against Alzheimer's beta -amyloid plaques via EFRH phage administration.

Authors:  D Frenkel; O Katz; B Solomon
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-10       Impact factor: 11.205

Review 2.  Alzheimer disease pathology as a host response.

Authors:  Rudy J Castellani; Hyoung-Gon Lee; Xiongwei Zhu; George Perry; Mark A Smith
Journal:  J Neuropathol Exp Neurol       Date:  2008-06       Impact factor: 3.685

Review 3.  Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta.

Authors:  Rudy J Castellani; Hyoung-gon Lee; Sandra L Siedlak; Akihiko Nunomura; Takaaki Hayashi; Masao Nakamura; Xiongwei Zhu; George Perry; Mark A Smith
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

4.  Mishandling of the therapeutic peptide glucagon generates cytotoxic amyloidogenic fibrils.

Authors:  Satomi Onoue; Keiichi Ohshima; Kazuhiro Debari; Keitatsu Koh; Seiji Shioda; Sumiko Iwasa; Kazuhisa Kashimoto; Takehiko Yajima
Journal:  Pharm Res       Date:  2004-07       Impact factor: 4.200
  4 in total

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