Increasing secondary metabolite production in plant-cell culture by redirecting transport.

Various approaches for redirecting transport of secondary metabolites in plant-cell suspension cultures have been attempted in an effort to increase productivity. Little is understood of the transport mechanisms or their regulation, and many of the extractive methods which involve membrane permeabilization have an adverse effect on cell viability. Increasing the activity of metabolic pathways by elicitation, in conjunction with end-product removal and accumulation in an extractive phase, has proven to be the most successful strategy so far.