Literature DB >> 7763269

Helicobacter pylori increases gene expression of hepatocyte growth factor in human gastric mucosa.

S Kondo1, Y Shinomura, S Kanayama, Y Higashimoto, T Kiyohara, Y Yasunaga, S Kitamura, H Ueyama, I Imamura, H Fukui.   

Abstract

Helicobacter pylori (H. pylori) induces hyperproliferation of the gastric mucosa. This study was designed to clarify whether H. pylori infection is involved in the gene expression of hepatocyte growth factor (HGF), a potent stimulator of cell proliferation in gastric mucosa. Levels of HGF mRNA were determined by a reverse transcription-polymerase chain reaction in endoscopic gastric biopsy specimens from 9 control subjects and 9 patients with H. pylori infection. In patients with H. pylori infection, levels of HGF mRNA in gastric mucosa were significantly higher than those in control subjects. HGF mRNA levels in patients with H. pylori infection were correlated with the severity of gastric mucosal inflammation. Our observations indicate that H. pylori infection increases the expression of HGF gene in gastric mucosa probably through the mucosal inflammation.

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Year:  1995        PMID： 7763269     DOI： 10.1006/bbrc.1995.1750

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Increased production of interleukin 1 beta and hepatocyte growth factor may contribute to foveolar hyperplasia in enlarged fold gastritis.

Authors:  Y Yasunaga; Y Shinomura; S Kanayama; Y Higashimoto; M Yabu; Y Miyazaki; S Kondo; Y Murayama; H Nishibayashi; S Kitamura; Y Matsuzawa
Journal:  Gut       Date:  1996-12       Impact factor: 23.059

2.  Cytokines and Helicobacter pylori--a growth area.

Authors:  R Playford
Journal:  Gut       Date:  1996-12       Impact factor: 23.059

3.  Helicobacter pylori gastritis and epithelial cell proliferation in patients with reflux oesophagitis after treatment with lansoprazole.

Authors:  A E Berstad; J G Hatlebakk; H Maartmann-Moe; A Berstad; P Brandtzaeg
Journal:  Gut       Date:  1997-12       Impact factor: 23.059

4.  Relation between clinical presentation, Helicobacter pylori density, interleukin 1beta and 8 production, and cagA status.

Authors:  Y Yamaoka; T Kodama; M Kita; J Imanishi; K Kashima; D Y Graham
Journal:  Gut       Date:  1999-12       Impact factor: 23.059

5.  High Fas ligand expression on lymphocytes in lesions of ulcerative colitis.

Authors:  H Ueyama; T Kiyohara; N Sawada; K Isozaki; S Kitamura; S Kondo; J Miyagawa; S Kanayama; Y Shinomura; H Ishikawa; T Ohtani; R Nezu; S Nagata; Y Matsuzawa
Journal:  Gut       Date:  1998-07       Impact factor: 23.059

6.  Increase in the circulating level of hepatocyte growth factor in gastric cancer patients.

Authors:  T Taniguchi; M Kitamura; K Arai; Y Iwasaki; Y Yamamoto; A Igari; M Toi
Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

7.  Met/HGF receptor modulates bcl-w expression and inhibits apoptosis in human colorectal cancers.

Authors:  S Kitamura; S Kondo; Y Shinomura; S Kanayama; Y Miyazaki; T Kiyohara; S Hiraoka; Y Matsuzawa
Journal:  Br J Cancer       Date:  2000-09       Impact factor: 7.640
  7 in total

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