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Literature DB >> 7762286

Viral oncoprotein binding to pRB, p107, p130, and p300.

Abstract

The purpose of this review is to bring attention to some additional work in the tumor virus/tumor suppressor field which may have been overshadowed by reports describing adenovirus, SV40, and HPV oncoprotein binding to pRB and p53. The data reviewed herein provide further support for the model that a common mechanism by which DNA tumor viruses transform cells involves inactivation of cellular proteins which function as negative regulators of cell growth.

Entities: Disease Gene

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Year: 1995 PMID： 7762286 DOI： 10.1016/0168-1702(94)00094-s

Source DB: PubMed Journal: Virus Res ISSN： 0168-1702 Impact factor: 3.303

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Cited

18 in total

1. The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.

Authors: N A Lanson; D B Egeland; B A Royals; W C Claycomb
Journal: Nucleic Acids Res Date: 2000-08-01 Impact factor: 16.971

2. RRB1 and RRB2 encode maize retinoblastoma-related proteins that interact with a plant D-type cyclin and geminivirus replication protein.

Authors: R A Ach; T Durfee; A B Miller; P Taranto; L Hanley-Bowdoin; P C Zambryski; W Gruissem
Journal: Mol Cell Biol Date: 1997-09 Impact factor: 4.272

3. Adding an Rb-binding site to an N-terminally truncated simian virus 40 T antigen restores growth to high cell density, and the T common region in trans provides anchorage-independent growth and rapid growth in low serum concentrations.

Authors: M J Tevethia; H A Lacko; T D Kierstead; D L Thompson
Journal: J Virol Date: 1997-03 Impact factor: 5.103

4. The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter.

Authors: W Zhang; D E Geiman; J M Shields; D T Dang; C S Mahatan; K H Kaestner; J R Biggs; A S Kraft; V W Yang
Journal: J Biol Chem Date: 2000-06-16 Impact factor: 5.157

5. Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.

Authors: A Mal; A Piotrkowski; M L Harter
Journal: J Virol Date: 1996-05 Impact factor: 5.103

Viral oncoprotein binding to pRB, p107, p130, and p300.

1. The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes.

2. RRB1 and RRB2 encode maize retinoblastoma-related proteins that interact with a plant D-type cyclin and geminivirus replication protein.

3. Adding an Rb-binding site to an N-terminally truncated simian virus 40 T antigen restores growth to high cell density, and the T common region in trans provides anchorage-independent growth and rapid growth in low serum concentrations.

4. The gut-enriched Kruppel-like factor (Kruppel-like factor 4) mediates the transactivating effect of p53 on the p21WAF1/Cip1 promoter.

5. Cyclin-dependent kinases phosphorylate the adenovirus E1A protein, enhancing its ability to bind pRb and disrupt pRb-E2F complexes.

Review 6. Molecular virology of Kaposi's sarcoma-associated herpesvirus.

7. Binding and Internalization of Iron Oxide Nanoparticles Targeted to Nuclear Oncoprotein.

8. Wild-type p53 enhances efficiency of simian virus 40 large-T-antigen-induced cellular transformation.

9. Adenovirus E1B55K region is required to enhance cyclin E expression for efficient viral DNA replication.

10. Mouse adenovirus type 1 early region 1A is dispensable for growth in cultured fibroblasts.