Literature DB >> 7762142

Nephrotoxicity and hepatotoxicity in calves apparently caused by experimental feeding with Narthecium ossifragum.

A Flåøyen1, B Bratberg, A Frøslie, H Grønstøl.   

Abstract

Seven calves were fed a mixture of bog plants containing 15 g (wet matter) Narthecium ossifragum per kg live weight for two consecutive days. Their serum creatinine, urea and magnesium concentrations increased, whereas the serum calcium concentration decreased. Histopathological examination of the kidneys of the 5 calves that were killed revealed tubular epithelial cell degeneration and necrosis. There were signs of liver dysfunction in all the calves including increased aspartate aminotransferase (ASAT), glutamate dehydrogenase (GLDH) and gamma-glutamyltransferase activities. All the calves refused to ingest N. ossifragum after 2 days feeding, and their appetite for hay and concentrate was also reduced. It can be concluded that N. ossifragum is nephrotoxic and hepatotoxic to calves.

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Year:  1995        PMID： 7762142     DOI： 10.1007/BF01839253

Source DB:  PubMed          Journal:  Vet Res Commun        ISSN： 0165-7380            Impact factor:   2.459


  8 in total

1.  Glycogen accumulation and histological changes in the livers of lambs with alveld and experimental sporidesmin intoxication.

Authors:  A Flåøyen; B Borrebaek; K Nordstoga
Journal:  Vet Res Commun       Date:  1991       Impact factor: 2.459

2.  Calcium effects on renal conservation of magnesium in cows.

Authors:  K Halse
Journal:  Acta Vet Scand       Date:  1984       Impact factor: 1.695

3.  Acute renal disorders in cattle: a retrospective study of 22 cases.

Authors:  T J Divers; W A Crowell; J R Duncan; R H Whitlock
Journal:  J Am Vet Med Assoc       Date:  1982-10-01       Impact factor: 1.936

4.  Bog asphodel (Narthecium ossifragum) poisoning in cattle.

Authors:  F E Malone; S Kennedy; G A Reilly; F M Woods
Journal:  Vet Rec       Date:  1992-08-01       Impact factor: 2.695

5.  Purification of toxic saponins from Narthecium asiaticum Maxim.

Authors:  M Kobayashi; K Suzuki; S Nagasawa; Y Mimaki
Journal:  J Vet Med Sci       Date:  1993-06       Impact factor: 1.267

6.  Failure to induce toxicity in lambs by administering saponins from Narthecium ossifragum.

Authors:  A Flåøyen; H Hjorth Tønnesen; H Grønstøl; J Karlsen
Journal:  Vet Res Commun       Date:  1991       Impact factor: 2.459

7.  Chronic renal failure and magnesium metabolism.

Authors:  R D Lindeman
Journal:  Magnesium       Date:  1986

8.  Narthecium asiaticum Maxim. Poisoning of grazing cattle: observations on spontaneous and experimental cases.

Authors:  K Suzuki; M Kobayashi; A Ito; M Nakgawa
Journal:  Cornell Vet       Date:  1985-04
  8 in total
  7 in total

1.  Toxicity testing of leaves from oak (Quercus robur) harvested in Aust-Agder county, Norway.

Authors:  A Flåøyen; K Handeland; J M Arnemo; T Vikøren
Journal:  Vet Res Commun       Date:  1999-08       Impact factor: 2.459

2.  Nephrotoxicity in goats caused by dosing with a water extract from the stems of Narthecium ossifragum plants.

Authors:  A Flåøyen; B Bratberg; A Frøslie; H Grønstøl; W Langseth; P G Mantle; A von Krogh
Journal:  Vet Res Commun       Date:  1997-10       Impact factor: 2.459

3.  Tolerance to the nephrotoxic component of Narthecium ossifragum in sheep: the effects of repeated oral doses of plant extracts.

Authors:  A Flåøyen; K Hove; A L Wilkins
Journal:  Vet Res Commun       Date:  2001-02       Impact factor: 2.459

4.  Metabolism of saponins from Narthecium ossifragum--a plant implicated in the aetiology of alveld, a hepatogenous photosensitization of sheep.

Authors:  A Flåøyen; A L Wilkins
Journal:  Vet Res Commun       Date:  1997-07       Impact factor: 2.459

5.  Further studies on the presence, qualities and effects of the toxic principles from Narthecium ossifragum plants.

Authors:  A Flåøyen; B Bratberg; A Frøslie; H Grønstøl; W Langseth; P G Mantle; A von Krogh
Journal:  Vet Res Commun       Date:  1997-02       Impact factor: 2.459

6.  Nephrotoxicity in lambs apparently caused by experimental feeding with Narthecium ossifragum.

Authors:  A Flåøyen; B Bratberg; H Grønstøl
Journal:  Vet Res Commun       Date:  1995       Impact factor: 2.459

7.  Accumulation of sapogenin conjugates and histological changes in the liver and kidneys of lambs suffering from alveld, a hepatogenous photosensitization disease of sheep grazing Narthecium ossifragum.

Authors:  H Wisløff; A L Wilkins; E Scheie; A Flåøyen
Journal:  Vet Res Commun       Date:  2002-07       Impact factor: 2.459
  7 in total

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