Literature DB >> 7761838

Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling.

A Kauffmann-Zeh1, G M Thomas, A Ball, S Prosser, E Cunningham, S Cockcroft, J J Hsuan.   

Abstract

Stimulation of phosphatidylinositol-4,5-bisphosphate (PIP2) hydrolysis is a widespread mechanism for receptor-mediated signaling in eukaryotes. Cytosolic phosphatidylinositol transfer protein (PITP) is necessary for guanosine triphosphate (GTP)-dependent hydrolysis of PIP2 by phospholipase C-beta (PLC-beta), but the role of PITP is unclear. Stimulation of phospholipase C-gamma (PLC-gamma) in A431 human epidermoid carcinoma cells treated with epidermal growth factor (EGF) required PITP. Stimulation of PI-4 kinase in cells treated with EGF also required PITP. Coprecipitation studies revealed an EGF-dependent association of PITP with the EGF receptor, with PI-4 kinase, and with PLC-gamma.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7761838     DOI： 10.1126/science.7761838

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  39 in total

1.  A unified model for signal transduction reactions in cellular membranes.

Authors:  Jason M Haugh
Journal:  Biophys J       Date:  2002-02       Impact factor: 4.033

2.  Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells.

Authors:  James G Alb; Scott E Phillips; Kathleen Rostand; Xiaoxia Cui; Jef Pinxteren; Laura Cotlin; Timothy Manning; Shuling Guo; John D York; Harald Sontheimer; James F Collawn; Vytas A Bankaitis
Journal:  Mol Biol Cell       Date:  2002-03       Impact factor: 4.138

3.  Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol 4,5-bisphosphate synthesis.

Authors:  G Way; N O'luanaigh; S Cockcroft
Journal:  Biochem J       Date:  2000-02-15       Impact factor: 3.857

4.  Identification and characterization of differentially active pools of type IIalpha phosphatidylinositol 4-kinase activity in unstimulated A431 cells.

Authors:  Mark G Waugh; Shane Minogue; Deena Blumenkrantz; J Simon Anderson; J Justin Hsuan
Journal:  Biochem J       Date:  2003-12-01       Impact factor: 3.857

5.  The yeast and mammalian isoforms of phosphatidylinositol transfer protein can all restore phospholipase C-mediated inositol lipid signaling in cytosol-depleted RBL-2H3 and HL-60 cells.

Authors:  E Cunningham; S K Tan; P Swigart; J Hsuan; V Bankaitis; S Cockcroft
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

Review 6.  The interface between phosphatidylinositol transfer protein function and phosphoinositide signaling in higher eukaryotes.

Authors:  Aby Grabon; Vytas A Bankaitis; Mark I McDermott
Journal:  J Lipid Res       Date:  2018-11-30       Impact factor: 5.922

7.  cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene.

Authors:  T B Geijtenbeek; A J Smith; P Borst; K W Wirtz
Journal:  Biochem J       Date:  1996-05-15       Impact factor: 3.857

Review 8.  Homeostatic regulation of the PI(4,5)P2-Ca(2+) signaling system at ER-PM junctions.

Authors:  Chi-Lun Chang; Jen Liou
Journal:  Biochim Biophys Acta       Date:  2016-02-24

9.  Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion.

Authors:  C Wiedemann; T Schäfer; M M Burger
Journal:  EMBO J       Date:  1996-05-01       Impact factor: 11.598

10.  Proteomic analysis of rat brains following exposure to electroconvulsive therapy.

Authors:  Cheol Soon Lee; Kee Ryeon Kang; Ji-Young Lee; Chul Soo Park; Kyu Hee Hahn; Jin Wook Sohn; Bong Jo Kim
Journal:  J Korean Med Sci       Date:  2009-02-28       Impact factor: 2.153
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.