Y Zhang1, R R Bailey. 1. Department of Nephrology, Christchurch Hospital.
Abstract
AIM: To assess the long term follow up of patients with reflux nephropathy. METHODS: Two hundred and ninety-four patients over 15 years of age (females 235; caucasians 288) presented between 3 wk and 72 yr of age (mean 17.3 yr; SD 14.4 yr). One hundred and seventy-six had unilateral reflux nephropathy and 118 had bilateral reflux nephropathy diagnosed on intravenous urography and/or a DMSA scintigraphy. RESULTS: The majority of patients, particularly women, presented with a urinary tract infection. Twenty-five patients (8.5%) had hypertension at presentation, 15 (5.1%) loin or abdominal pain, 14 (4.8%) proteinuria and six (2%) renal insufficiency. At the last follow up (mean age 34.2yr; SD 13.7yr; range 15-81yr), 113 patients (38%) had hypertension or were on antihypertensive therapy. This was significantly more frequent in those with severe bilateral renal parenchymal scarring. Proteinuria was present in 92 (31%); 40 of these had renal insufficiency. Seventy-one (24%) had a creatinine clearance < 70 mL/min and 43 (15%) a urinary tract infection. Eighteen patients had suffered from a urinary calculus. Proteinuria and renal insufficiency were significantly more frequent in those with severe bilateral reflux nephropathy. CONCLUSION: All patients with reflux nephropathy who have proteinuria, hypertension or renal insufficiency should be under regular follow up.
AIM: To assess the long term follow up of patients with reflux nephropathy. METHODS: Two hundred and ninety-four patients over 15 years of age (females 235; caucasians 288) presented between 3 wk and 72 yr of age (mean 17.3 yr; SD 14.4 yr). One hundred and seventy-six had unilateral reflux nephropathy and 118 had bilateral reflux nephropathy diagnosed on intravenous urography and/or a DMSA scintigraphy. RESULTS: The majority of patients, particularly women, presented with a urinary tract infection. Twenty-five patients (8.5%) had hypertension at presentation, 15 (5.1%) loin or abdominal pain, 14 (4.8%) proteinuria and six (2%) renal insufficiency. At the last follow up (mean age 34.2yr; SD 13.7yr; range 15-81yr), 113 patients (38%) had hypertension or were on antihypertensive therapy. This was significantly more frequent in those with severe bilateral renal parenchymal scarring. Proteinuria was present in 92 (31%); 40 of these had renal insufficiency. Seventy-one (24%) had a creatinine clearance < 70 mL/min and 43 (15%) a urinary tract infection. Eighteen patients had suffered from a urinary calculus. Proteinuria and renal insufficiency were significantly more frequent in those with severe bilateral reflux nephropathy. CONCLUSION: All patients with reflux nephropathy who have proteinuria, hypertension or renal insufficiency should be under regular follow up.
Authors: Jose Maria Penido Silva; Jose Silverio Santos Diniz; Ana Cristina Simões Silva; Marcus V Azevedo; Mariana R Pimenta; Eduardo Araujo Oliveira Journal: Pediatr Nephrol Date: 2006-06-22 Impact factor: 3.714
Authors: Heather J Lambert; Aisling Stewart; Ambrose M Gullett; Heather J Cordell; Sue Malcolm; Sally A Feather; Judith A Goodship; Timothy H J Goodship; Adrian S Woolf Journal: Clin J Am Soc Nephrol Date: 2011-03-24 Impact factor: 8.237
Authors: Ana C Simoes e Silva; Jose Maria P Silva; Jose Silverio S Diniz; Sérgio V B Pinheiro; Eleonora M Lima; Mariana A Vasconcelos; Mariana R Pimenta; Eduardo A Oliveira Journal: Pediatr Nephrol Date: 2006-12-02 Impact factor: 3.714