| Literature DB >> 7760983 |
Abstract
The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was investigated in the ferret over a 72 and 24 hr period respectively. The 5-HT3 receptor antagonists ondansetron and alosetron markedly antagonized or abolished the emesis during the "acute phase" and, whilst antagonizing the emesis during the delayed phase, also revealed a 5-HT3 receptor antagonist resistant component. These cisplatin paradigms may provide models relevant to the study of acute and delayed emesis induced by cisplatin in man.Entities:
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Year: 1994 PMID： 7760983 DOI： 10.1016/0028-3908(94)90136-8
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250