| Literature DB >> 7760429 |
M Li1, J Yang, G X Shen, Q Zhang, S P Liu, Z B Liu, W X Ye.
Abstract
T cell activation and proliferation via CD3-TCR complex were investigated by lymphocyte DNA synthesis in vitro. Several interfering factors were also discussed. The result indicated that lymphocyte activation and proliferation are calcium-dependent. A rise of cytoplasmic free Ca2+ quickly following activation with CD3 McAb is mainly due to intracellular mobilization of Ca2+, while lymphocyte proliferation needs both intracellular mobilization of Ca2+ as well as influx of extracellular Ca2+. It was confirmed that CTX sensitive G protein plays a role in regulating T cell proliferation by pretreatment with CTX suppressing lymphocyte H-TdR incorporation obviously. PLC and PKC inhibitor neomycin and P. S. S could also decrease T cell proliferation.Entities:
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Year: 1994 PMID： 7760429 DOI： 10.1007/BF02897669
Source DB: PubMed Journal: J Tongji Med Univ ISSN： 0257-716X