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Literature DB >> 7760373

The contribution of ionic imbalance to ischemia/reperfusion-induced injury.

Abstract

Recent data from a number of independent laboratories have implicated ionic disturbances within the myocardium as being a critical contributory factor in injury to the heart during ischemia/reperfusion. The present treatise discusses the data supporting a role for Ca2+, Na+ and K+ in ischemic/reperfusion injury. The mechanism whereby intracellular ionic homeostasis becomes altered is the focus of the review. In particular, the evidence in support of an involvement of abnormal ion movements through Na+/H+ exchange, Na+ channels and the ATP-sensitive K+ channel in ischemic/reperfusion injury is advanced.

Entities: Chemical Disease

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Year: 1995 PMID： 7760373 DOI： 10.1016/s0022-2828(08)80007-7

Source DB: PubMed Journal: J Mol Cell Cardiol ISSN： 0022-2828 Impact factor: 5.000

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Cited

32 in total

1. Is "Lethal Reperfusion" an Oxymoron?

Authors:
Journal: J Thromb Thrombolysis Date: 1997-01 Impact factor: 2.300

2. Multinuclear MR-spectroscopy on ion-homeostasis and energetics during ischemia and reperfusion.

Authors: U K Decking; L Vogler; M Hartmann; J Schrader
Journal: MAGMA Date: 2000-11 Impact factor: 2.310

3. Simultaneous maps of optical action potentials and calcium transients in guinea-pig hearts: mechanisms underlying concordant alternans.

Authors: B R Choi; G Salama
Journal: J Physiol Date: 2000-11-15 Impact factor: 5.182

4. BNIP3 promotes calcium and calpain-dependent cell death.

Authors: Regina M Graham; John W Thompson; Keith A Webster
Journal: Life Sci Date: 2015-10-21 Impact factor: 5.037

5. Blocking effect of methylflavonolamine on human Na(V)1.5 channels expressed in Xenopus laevis oocytes and on sodium currents in rabbit ventricular myocytes.

Authors: Xin-rong Fan; Ji-hua Ma; Pei-hua Zhang; Jun-lian Xing
Journal: Acta Pharmacol Sin Date: 2010-02-22 Impact factor: 6.150

10. Effects of chronic hypoxia on inward rectifier K(+) current ( I(K1)) in ventricular myocytes of crucian carp (Carassius carassius) heart.

Authors: V Paajanen; M Vornanen
Journal: J Membr Biol Date: 2003-07-15 Impact factor: 1.843

The contribution of ionic imbalance to ischemia/reperfusion-induced injury.

1. Is "Lethal Reperfusion" an Oxymoron?

2. Multinuclear MR-spectroscopy on ion-homeostasis and energetics during ischemia and reperfusion.

3. Simultaneous maps of optical action potentials and calcium transients in guinea-pig hearts: mechanisms underlying concordant alternans.

4. BNIP3 promotes calcium and calpain-dependent cell death.

5. Blocking effect of methylflavonolamine on human Na(V)1.5 channels expressed in Xenopus laevis oocytes and on sodium currents in rabbit ventricular myocytes.

6. Effects of hypoxia, simulated ischemia and reoxygenation on the contractile function of human atrial trabeculae.

7. Localized injury in cardiomyocyte network: a new experimental model of ischemia-reperfusion arrhythmias.

8. R 56865 exerts cardioprotective properties independent of the intracellular Na(+)-overload in the guinea pig heart.

9. Effects of trimetazidine on pHi regulation in the rat isolated ventricular myocyte.

10. Effects of chronic hypoxia on inward rectifier K(+) current ( I(K1)) in ventricular myocytes of crucian carp (Carassius carassius) heart.