| Literature DB >> 7759666 |
A E Walsh1, A D Oldman, M Franklin, C G Fairburn, P J Cowen.
Abstract
We studied the effect of 3 weeks of moderate calorie restriction on 5-HT-mediated prolactin (PRL) release in healthy volunteers using the 5-HT-releasing agent d-fenfluramine. In women, dieting significantly lowered plasma total and free tryptophan (TRP) and increased the PRL response to d-fenfluramine. None of these measures were altered in men who dieted. These findings add to the data indicating that dieting alters brain 5-HT function in women, perhaps as a consequence of reducing the availability of plasma TRP.Entities:
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Year: 1995 PMID： 7759666 DOI： 10.1016/0165-0327(94)00078-n
Source DB: PubMed Journal: J Affect Disord ISSN： 0165-0327 Impact factor: 4.839