Literature DB >> 7759116

Chromosomal localization of the gamma-glutamyl carboxylase gene at 2p12.

W L Kuo1, D W Stafford, J Cruces, J Gray, J Solera.   

Abstract

We have used two complementary approaches to analyze the chromosomal location of the gamma-glutamyl carboxylase gene. The amplification of a carboxylase-specific genomic fragment by polymerase chain reaction (PCR) in a human-rodent hybrid cell mapping panel localized the gene to chromosome 2. Mapping by fluorescence in situ hybridization assigned the gene to p12 of chromosome 2. Our results indicate that the gamma-glutamyl carboxylase gene has a single locus in the human genome.

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Year:  1995        PMID： 7759116     DOI： 10.1016/0888-7543(95)80024-g

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  9 in total

Review 1.  Pharmacogenetics of target genes across the warfarin pharmacological pathway.

Authors:  Suman Lal; Srinivasa Rao Jada; Xiaoqiang Xiang; Wan-Teck Lim; Edmund J D Lee; Balram Chowbay
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

2.  Compound heterozygosity of novel missense mutations in the gamma-glutamyl-carboxylase gene causes hereditary combined vitamin K-dependent coagulation factor deficiency.

Authors:  Dhouha Darghouth; Kevin W Hallgren; Rebecca L Shtofman; Amel Mrad; Youssef Gharbi; Ahmed Maherzi; Radhia Kastally; Sophie LeRicousse; Kathleen L Berkner; Jean-Philippe Rosa
Journal:  Blood       Date:  2006-05-23       Impact factor: 22.113

3.  Genetic mutation of vitamin K-dependent gamma-glutamyl carboxylase domain in patients with calcium oxalate urolithiasis.

Authors:  Jiankun Qiao; Tao Wang; Jun Yang; Jihong Liu; Xiaoxin Gong; Xiaolin Guo; Shaogang Wang; Zhangqun Ye
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2009-10-11

Review 4.  Pharmacogenetics of oral anticoagulants: a basis for dose individualization.

Authors:  Simone Stehle; Julia Kirchheiner; Andreas Lazar; Uwe Fuhr
Journal:  Clin Pharmacokinet       Date:  2008       Impact factor: 6.447

5.  High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population.

Authors:  Pei-Chieng Cha; Taisei Mushiroda; Atsushi Takahashi; Shigeru Saito; Hideki Shimomura; Takao Suzuki; Naoyuki Kamatani; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2007-09-05       Impact factor: 3.172

6.  Association of sequence variations in vitamin K epoxide reductase and gamma-glutamyl carboxylase genes with biochemical measures of vitamin K status.

Authors:  Michael D Crosier; Inga Peter; Sarah L Booth; Grace Bennett; Bess Dawson-Hughes; Jose M Ordovas
Journal:  J Nutr Sci Vitaminol (Tokyo)       Date:  2009-04       Impact factor: 2.000

Review 7.  Structural and functional insights into enzymes of the vitamin K cycle.

Authors:  J-K Tie; D W Stafford
Journal:  J Thromb Haemost       Date:  2016-01-29       Impact factor: 5.824

Review 8.  Association of genetic polymorphisms with warfarin dose requirements in Chinese patients.

Authors:  Yundan Liang; Zhiyu Chen; Gang Guo; Xuemei Dong; Chunting Wu; He Li; Tong Wang; Bingying Xu
Journal:  Genet Test Mol Biomarkers       Date:  2013-08-13

9.  Suspected vitamin K-dependent coagulation factor deficiency in pregnancy: A case report.

Authors:  Mariam Ayyash; Meera Chitlur; Johannes Oldenburg; Majid Shaman
Journal:  Case Rep Womens Health       Date:  2022-04-27
  9 in total

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