Literature DB >> 7759089

Characterisation of three microsatellite polymorphisms (D21S1262, D21S1419 and D21S1421) from band 21q22.1.

A Bosch1, J Guimerà, D Patterson, X Estivill.   

Abstract

We have isolated three clones, containing highly polymorphic CA-repeat sequences, from a human chromosome 21 phage library (LA21NS01). These clones have been localised to band q22.1 by using a chromosome 21 somatic cell hybrid panel. D21S1262 is located between breakpoints 6918-8a1 and 3x2S, and D21S1419 and D21S1421 are localised between breakpoints JC6-A and MRC2G. Their observed heterozygosities range between 0.75 and 0.85 as shown by unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These highly polymorphic markers should be useful for improving the analysis of this region of chromosome 21, which contains important genes such as SOD1, GART and IFNAR.

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Year:  1995        PMID： 7759089     DOI： 10.1007/BF00223881

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  8 in total

Review 1.  La carte des microsatellites est arrivée! [The map of microsatellites has arrived!].

Authors:  J A Todd
Journal:  Hum Mol Genet       Date:  1992-12       Impact factor: 6.150

2.  Partial physical map of human chromosome 21.

Authors:  K Gardiner; P Watkins; M Münke; H Drabkin; C Jones; D Patterson
Journal:  Somat Cell Mol Genet       Date:  1988-11

3.  Isolation and characterization of 14 CA-repeat microsatellites from human chromosome 21.

Authors:  A Bosch; V Nunes; D Patterson; X Estivill
Journal:  Genomics       Date:  1993-10       Impact factor: 5.736

4.  A linkage map of human chromosome 21:43 PCR markers at average intervals of 2.5 cM.

Authors:  M G McInnis; A Chakravarti; J Blaschak; M B Petersen; V Sharma; D Avramopoulos; J L Blouin; U König; C Brahe; T C Matise
Journal:  Genomics       Date:  1993-06       Impact factor: 5.736

5.  Informativeness of human (dC-dA)n.(dG-dT)n polymorphisms.

Authors:  J L Weber
Journal:  Genomics       Date:  1990-08       Impact factor: 5.736

Review 6.  Human chromosome 21: genome mapping and exploration, circa 1993.

Authors:  S E Antonarakis
Journal:  Trends Genet       Date:  1993-04       Impact factor: 11.639

7.  Receptors for human alpha and beta interferon but not for gamma interferon are specified by human chromosome 21.

Authors:  A Raziuddin; F H Sarkar; R Dutkowski; L Shulman; F H Ruddle; S L Gupta
Journal:  Proc Natl Acad Sci U S A       Date:  1984-09       Impact factor: 11.205

8.  Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

Authors:  K Gardiner; M Horisberger; J Kraus; U Tantravahi; J Korenberg; V Rao; S Reddy; D Patterson
Journal:  EMBO J       Date:  1990-01       Impact factor: 11.598
  8 in total

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