| Literature DB >> 7757956 |
S Nakajima1, T Takemura, I Sakata.
Abstract
We spectrochemically analyzed 12 Ga-Metal porphyrins (Ga-Cn-P) with different degrees of hydrophobicity, and observed a close association between the in vivo Ga-Cn-P localization in the tumor and its affinity to transferrin and LDL. Image analysis of tumors with 99m-Tc-STA-R12, a porphyrin-scintigraphic agent, revealed STA-R12 localization in the tumor tissue alone about 1 h after intravenous infusion. Our results suggest the importance of endocytosis mediated by transferrin as well as LDL that have been reported as a mechanism of the tumor-localizing activity of porphyrin.Entities:
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Year: 1995 PMID： 7757956 DOI： 10.1016/0304-3835(95)03762-l
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679