Literature DB >> 7757268

Neutralizing anti-p21ras Fabs suppress rat sympathetic neuron survival induced by NGF, LIF, CNTF and cAMP.

C D Nobes1, A M Tolkovsky.   

Abstract

In purified cultures of newly isolated rat sympathetic neurons plated on laminin, apoptosis is suppressed by the cytokines leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF), by the permeant cAMP analogue 8-(4-chlorophenylthio)cAMP, and by nerve growth factor. Whilst nerve growth factor, 8-(4-chlorophenylthio)cAMP and LIF/CNTF initiate survival by using different kinases, in each case survival is inhibited by a Fab fragment of Y13-259, a neutralizing antibody to p21ras proteins, but not by rat IgG Fab. The inhibitory effect of Y13-259 could be partially attenuated by cotrituration of the Fab with T'24(inactive)ras. Thus, prevention of apoptosis in rat sympathetic neurons by several different survival factors appears to be critically dependent on p21ras protein activity.

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Year:  1995        PMID： 7757268     DOI： 10.1111/j.1460-9568.1995.tb01069.x

Source DB:  PubMed          Journal:  Eur J Neurosci        ISSN： 0953-816X            Impact factor:   3.386


  14 in total

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2.  Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway.

Authors:  A C Maroney; M A Glicksman; A N Basma; K M Walton; E Knight; C A Murphy; B A Bartlett; J P Finn; T Angeles; Y Matsuda; N T Neff; C A Dionne
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4.  Ras guanine nucleotide releasing factor 1 (RasGrf1) enhancement of Trk receptor-mediated neurite outgrowth requires activation of both H-Ras and Rac.

Authors:  Asghar Talebian; Kim Robinson-Brookes; James I S MacDonald; Susan O Meakin
Journal:  J Mol Neurosci       Date:  2012-06-29       Impact factor: 3.444

5.  Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway.

Authors:  C Y Yan; L A Greene
Journal:  J Neurosci       Date:  1998-06-01       Impact factor: 6.167

6.  The Plasma Membrane as a Competitive Inhibitor and Positive Allosteric Modulator of KRas4B Signaling.

Authors:  Chris Neale; Angel E García
Journal:  Biophys J       Date:  2020-01-22       Impact factor: 4.033

Review 7.  Activity-dependent neurotrophic factor (ADNF). An extracellular neuroprotective chaperonin?

Authors:  I Gozes; D E Brenneman
Journal:  J Mol Neurosci       Date:  1996       Impact factor: 3.444

8.  BDNF is involved in sympathetic sprouting in the dorsal root ganglia following peripheral nerve injury in rats.

Authors:  Y S Deng; J H Zhong; X F Zhou
Journal:  Neurotox Res       Date:  2000-04       Impact factor: 3.911

9.  A role for MAPK/ERK in sympathetic neuron survival: protection against a p53-dependent, JNK-independent induction of apoptosis by cytosine arabinoside.

Authors:  C N Anderson; A M Tolkovsky
Journal:  J Neurosci       Date:  1999-01-15       Impact factor: 6.167

10.  p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons.

Authors:  L J Klesse; L F Parada
Journal:  J Neurosci       Date:  1998-12-15       Impact factor: 6.167
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