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Literature DB >> 7756115

Why do adipocytes make the beta 3 adrenergic receptor?

Abstract

Adipocytes express a mixture of beta-adrenergic receptor subtypes, including the recently characterized beta 3 receptor. The co-expression of these subtypes by fat cells suggest they serve different signalling functions. In this review, the properties of recombinant and natively-expressed beta 3 receptors are detailed and contrasted with those of beta 1 and beta 2 receptors. The beta 3 receptor appears to differ from the other beta receptor subtypes with respect to receptor coupling efficiency, G-protein coupling specificity and regulation by agonist exposure. Lastly, the potential of the beta 3 receptor as a therapeutic target is discussed in view of new data regarding its tissue distribution in humans.

Entities: Gene Species

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Year: 1995 PMID： 7756115 DOI： 10.1016/0898-6568(94)00066-k

Source DB: PubMed Journal: Cell Signal ISSN： 0898-6568 Impact factor: 4.315

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Cited

11 in total

1. beta3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK.

Authors: Emilio P Mottillo; Xiang Jun Shen; James G Granneman
Journal: Biochim Biophys Acta Date: 2010-05-07

2. Biphasic effects of the beta-adrenoceptor agonist, BRL 37344, on glucose utilization in rat isolated skeletal muscle.

Authors: Y L Liu; M A Cawthorne; M J Stock
Journal: Br J Pharmacol Date: 1996-03 Impact factor: 8.739

3. Effect of β(3)-adrenergic receptor gene polymorphism on body weight change in middle-aged, overweight women.

Authors: Jung Su Lee; Kiyoshi Kawakubo; Shuji Inoue; Akira Akabayashi
Journal: Environ Health Prev Med Date: 2006-03 Impact factor: 3.674

4. Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues.

Authors: C Deng; A Paoloni-Giacobino; F Kuehne; O Boss; J P Revelli; M Moinat; M A Cawthorne; P Muzzin; J P Giacobino
Journal: Br J Pharmacol Date: 1996-06 Impact factor: 8.739

5. Prolonged treatment with the beta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 2) modulation of glucose uptake and monoamine oxidase activity.

Authors: C Duffaut; S Bour; D Prévot; L Marti; X Testar; A Zorzano; C Carpéné
Journal: J Physiol Biochem Date: 2006-06 Impact factor: 5.080

6. Prolonged treatment with the beta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 1) fat store depletion and desensitization of beta-adrenergic responses.

Authors: C Ferrand; A Redonnet; D Prévot; C Carpéné; C Atgié
Journal: J Physiol Biochem Date: 2006-06 Impact factor: 5.080

Why do adipocytes make the beta 3 adrenergic receptor?

1. beta3-adrenergic receptor induction of adipocyte inflammation requires lipolytic activation of stress kinases p38 and JNK.

2. Biphasic effects of the beta-adrenoceptor agonist, BRL 37344, on glucose utilization in rat isolated skeletal muscle.

3. Effect of β(3)-adrenergic receptor gene polymorphism on body weight change in middle-aged, overweight women.

4. Respective degree of expression of beta 1-, beta 2- and beta 3-adrenoceptors in human brown and white adipose tissues.

5. Prolonged treatment with the beta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 2) modulation of glucose uptake and monoamine oxidase activity.

6. Prolonged treatment with the beta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 1) fat store depletion and desensitization of beta-adrenergic responses.

Review 7. Nutrition in the intensive care unit.

8. Role of beta3-adrenergic receptors in the action of a tumour lipid mobilizing factor.

9. Angiotensin II Stimulates Sympathetic Neurotransmission to Adipose Tissue.

10. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41.