OBJECTIVE: The authors examined the efficacy of methylphenidate in the treatment of depression in a group of older, medically ill patients. METHOD:Sixteen patients underwent an 8-day double-blind, randomized, placebo-controlled crossover trial; 13 completed the trial. RESULTS: Statistically and clinically significant treatment responses were found. CONCLUSIONS: These results support the use of methylphenidate in older, medically ill patients in whom rapid resolution of depressive symptoms is crucial.
RCT Entities:
OBJECTIVE: The authors examined the efficacy of methylphenidate in the treatment of depression in a group of older, medically ill patients. METHOD: Sixteen patients underwent an 8-day double-blind, randomized, placebo-controlled crossover trial; 13 completed the trial. RESULTS: Statistically and clinically significant treatment responses were found. CONCLUSIONS: These results support the use of methylphenidate in older, medically ill patients in whom rapid resolution of depressive symptoms is crucial.
Authors: Ellen M Whyte; Mary Amanda Dew; Ariel Gildengers; Eric J Lenze; Ashok Bharucha; Benoit H Mulsant; Charles F Reynolds Journal: Drugs Aging Date: 2004 Impact factor: 3.923
Authors: Donald R Sullivan; Solange Mongoue-Tchokote; Motomi Mori; Elizabeth Goy; Linda Ganzini Journal: Psychooncology Date: 2016-08-12 Impact factor: 3.894
Authors: Lea T Drye; Roberta W Scherer; Krista L Lanctôt; Paul B Rosenberg; Nathan Herrmann; David Bachman; Jacobo E Mintzer Journal: Am J Geriatr Psychiatry Date: 2013-01-18 Impact factor: 4.105