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Literature DB >> 7753975

The short-term effect of nicotine chewing gum in patients with Parkinson's disease.

P Clemens¹, J A Baron, D Coffey, A Reeves.

Abstract

Because of the inverse association of cigarette smoking with the risk of Parkinson's disease, we performed a short-term, double-blind, randomized controlled trial of nicotine polacrilex resin gum in patients with this disease. Forty-eight subjects were randomly assigned to chew either nicotine gum or placebo gum three times at 2-h intervals, with evaluation of symptoms before and after the trial. The nicotine gum was reasonably well tolerated, but there were no substantial differences in Parkinson's disease symptoms between the two treatment groups.

Entities: Chemical Disease Species

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Year: 1995 PMID： 7753975 DOI： 10.1007/BF02245195

Source DB: PubMed Journal: Psychopharmacology (Berl) ISSN： 0033-3158 Impact factor: 4.530

20 in total

Review 1. Levodopa: a review of its pharmacological properties and therapeutic use with particular reference to Parkinsonism.

Authors: R N Brogden; T M Speight; G S Avery
Journal: Drugs Date: 1971 Impact factor: 9.546

Review 2. Cigarette smoking and Parkinson's disease.

Authors: J A Baron
Journal: Neurology Date: 1986-11 Impact factor: 9.910

3. Chronic nicotine treatment eliminates asymmetry in striatal glucose utilization following unilateral transection of the mesostriatal dopamine pathway in rats.

Authors: C Owman; K Fuxe; A M Janson; J Kåhrström
Journal: Neurosci Lett Date: 1989-07-31 Impact factor: 3.046

4. Effects of smoking in patients with early-onset Parkinson's disease.

Authors: A Ishikawa; T Miyatake
Journal: J Neurol Sci Date: 1993-07 Impact factor: 3.181

5. Should levodopa therapy for Parkinsonism be started early or late? Evidence against early treatment.

Authors: S Fahn; S B Bressman
Journal: Can J Neurol Sci Date: 1984-02 Impact factor: 2.104

6. Effect of adrenaline, noradrenaline, atropine, and nicotine on some types of human tremor.

Authors: J Marshall; H Schnieden
Journal: J Neurol Neurosurg Psychiatry Date: 1966-06 Impact factor: 10.154

7. Effect of chronic oral nicotine on dopaminergic function in the MPTP-treated mouse.

Authors: H Sershen; A Hashim; H L Wiener; A Lajtha
Journal: Neurosci Lett Date: 1988-11-11 Impact factor: 3.046

8. Dopamine-like action of nicotine: lack of tolerance and reverse tolerance.

Authors: E P Lapin; H S Maker; H Sershen; Y Hurd; A Lajtha
Journal: Brain Res Date: 1987-03-31 Impact factor: 3.252

9. Inhibition of uptake of 1-methyl-4-phenylpyridinium ion and dopamine in striatal synaptosomes by tobacco smoke components.

Authors: L A Carr; J K Basham; B K York; P P Rowell
Journal: Eur J Pharmacol Date: 1992-05-14 Impact factor: 4.432

10. Nicotine enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.

Authors: R A Behmand; S I Harik
Journal: J Neurochem Date: 1992-02 Impact factor: 5.372

25 in total

1. Effects of nicotine chewing gum on a real-life motor task: a kinematic analysis of handwriting movements in smokers and non-smokers.

Authors: Oliver Tucha; Klaus W Lange
Journal: Psychopharmacology (Berl) Date: 2003-12-11 Impact factor: 4.530

The short-term effect of nicotine chewing gum in patients with Parkinson's disease.

Review 1. Levodopa: a review of its pharmacological properties and therapeutic use with particular reference to Parkinsonism.

Review 2. Cigarette smoking and Parkinson's disease.

3. Chronic nicotine treatment eliminates asymmetry in striatal glucose utilization following unilateral transection of the mesostriatal dopamine pathway in rats.

4. Effects of smoking in patients with early-onset Parkinson's disease.

5. Should levodopa therapy for Parkinsonism be started early or late? Evidence against early treatment.

6. Effect of adrenaline, noradrenaline, atropine, and nicotine on some types of human tremor.

7. Effect of chronic oral nicotine on dopaminergic function in the MPTP-treated mouse.

8. Dopamine-like action of nicotine: lack of tolerance and reverse tolerance.

9. Inhibition of uptake of 1-methyl-4-phenylpyridinium ion and dopamine in striatal synaptosomes by tobacco smoke components.

10. Nicotine enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity.

1. Effects of nicotine chewing gum on a real-life motor task: a kinematic analysis of handwriting movements in smokers and non-smokers.

Review 2. α6β2* and α4β2* nicotinic acetylcholine receptors as drug targets for Parkinson's disease.

Review 3. Targeting nicotinic receptors for Parkinson's disease therapy.

4. Nicotine reduces established levodopa-induced dyskinesias in a monkey model of Parkinson's disease.

5. Chronic nicotine improves cognitive and social impairment in mice overexpressing wild type α-synuclein.

Review 6. Potential Therapeutic Application for Nicotinic Receptor Drugs in Movement Disorders.

7. The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats.

Review 8. Nicotine and inflammatory neurological disorders.

Review 9. Disease-Toxicant Interactions in Parkinson's Disease Neuropathology.

Review 10. Nicotine and Parkinson's disease: implications for therapy.