Literature DB >> 7753928

Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro.

V C Njar, T O Alao, J I Okogun, Y Raji, A F Bolarinwa, E U Nduka.   

Abstract

The crude methanol extract of the stem wood of Quassia amara L. inhibited both the basal and LH-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion. Fractionation of the extract by chromatography gave quassin (1) and 2-methoxycanthin-6-one (2); compound 1 proved to be the bioactive agent.

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Year:  1995        PMID： 7753928     DOI： 10.1055/s-2006-958044

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  3 in total

1.  Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats.

Authors:  Yinusa Raji; Ganiyat Kehinde Oloyede
Journal:  Afr J Tradit Complement Altern Med       Date:  2011-10-02

2.  Comprehensive assessment of the effect of Sphenocentrum jollyanum root extract on male reproductive activity in albino rats.

Authors:  Yinusa Raji; Olayemi O Fadare; Rahmat A Adisa; Shakiru A Salami
Journal:  Reprod Med Biol       Date:  2006-11-23

3.  Impact of the malaria parasite on reproductive indices of male mice.

Authors:  Yinusa Raji; Olumide S Akinsomisoye; Mistura O Azeez
Journal:  Reprod Med Biol       Date:  2006-08-09
  3 in total

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