Literature DB >> 7753927

In vitro and in vivo antitumoral phenanthrenes from the aerial parts of Dendrobium nobile.

Y H Lee, J D Park, N I Baek, S I Kim, B Z Ahn.   

Abstract

Two phenanthrenes were isolated from the aerial part of Dendrobium nobile Lindl. and their structures were identified to be 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene (1) and denbinobin (2), among which the former has been first isolated from this plant. These two compounds were found to be cytotoxic against A549 (human lung carcinoma), SK-OV-3 (human ovary adenocarcinoma), and HL-60 (human promyelocytic leukemia) cell lines. Compound 1 also showed antitumor activity on the life span of ICR mice intraperitoneally implanted with 1 x 10(6) cells of sarcoma 180.

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Year:  1995        PMID： 7753927     DOI： 10.1055/s-2006-958043

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  18 in total

1.  In vitro cytotoxic screening of selected Saudi medicinal plants.

Authors:  Hussein Almehdar; Hossam M Abdallah; Abdel-Moneim M Osman; Essam A Abdel-Sattar
Journal:  J Nat Med       Date:  2011-09-28       Impact factor: 2.343

2.  Escaping immune surveillance in cancer: is denbinobin the panacea?

Authors:  Tapiwanashe Magwere
Journal:  Br J Pharmacol       Date:  2009-08       Impact factor: 8.739

3.  Dendrobium protoplast co-culture promotes phytochemical assemblage in vitro.

Authors:  Abitha Thomas; Ipsita Pujari; Vasudeep Shetty; Manjunath B Joshi; Padmalatha S Rai; Kapaettu Satyamoorthy; Vidhu Sankar Babu
Journal:  Protoplasma       Date:  2016-11-11       Impact factor: 3.356

4.  Molecular mechanisms of denbinobin-induced anti-tumorigenesis effect in colon cancer cells.

Authors:  Kuo-Ching Yang; Yih-Huei Uen; Fat-Moon Suk; Yu-Chih Liang; Ying-Jan Wang; Yuan-Soon Ho; I-Hsuan Li; Shyr-Yi Lin
Journal:  World J Gastroenterol       Date:  2005-05-28       Impact factor: 5.742

5.  Denbinobin induces apoptosis by apoptosis-inducing factor releasing and DNA damage in human colorectal cancer HCT-116 cells.

Authors:  Tzu-Hsuan Chen; Shiow-Lin Pan; Jih-Hwa Guh; Chien-Chih Chen; Yao-Ting Huang; Hui-Chen Pai; Che-Ming Teng
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-07-08       Impact factor: 3.000

6.  Combined treatment with denbinobin and Fas ligand has a synergistic cytotoxic effect in human pancreatic adenocarcinoma BxPC-3 cells.

Authors:  C R Yang; J H Guh; C M Teng; C C Chen; P H Chen
Journal:  Br J Pharmacol       Date:  2009-05-18       Impact factor: 8.739

7.  Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids.

Authors:  Nirav Kapadia; Wayne Harding
Journal:  Tetrahedron       Date:  2013-10-21       Impact factor: 2.457

8.  Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis.

Authors:  Chia-Lin Lee; Fang-Rong Chang; Ming-Hon Yen; Donglei Yu; Yi-Nan Liu; Kenneth F Bastow; Susan L Morris-Natschke; Yang-Chang Wu; Kuo-Hsiung Lee
Journal:  J Nat Prod       Date:  2009-02-27       Impact factor: 4.050

Review 9.  Evaluation of chemical constituents and important mechanism of pharmacological biology in dendrobium plants.

Authors:  Yau Lam; Tzi Bun Ng; Ren Ming Yao; Jun Shi; Kai Xu; Stephen Cho Wing Sze; Kalin Yanbo Zhang
Journal:  Evid Based Complement Alternat Med       Date:  2015-04-06       Impact factor: 2.629

10.  Apoptosis signal-regulating kinase 1 mediates denbinobin-induced apoptosis in human lung adenocarcinoma cells.

Authors:  Chen-Tzu Kuo; Bing-Chang Chen; Chung-Chi Yu; Chih-Ming Weng; Ming-Jen Hsu; Chien-Chih Chen; Mei-Chieh Chen; Che-Ming Teng; Shiow-Lin Pan; Mauo-Ying Bien; Chung-Hung Shih; Chien-Huang Lin
Journal:  J Biomed Sci       Date:  2009-05-01       Impact factor: 8.410
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