Literature DB >> 7753926

In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates.

H H Ang, K L Chan, J W Mak.   

Abstract

Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-beta-D-glucopyranoside, and 13 beta, 18-dihydroeurycomanol possessed antimalarial activity with IC50 values of 1.231-4.899 microM, 0.389-3.498 microM, and 0.504-2.343 microM, respectively, compared with 0.323-0.774 microM for chloroquine.

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Year:  1995        PMID： 7753926     DOI： 10.1055/s-2006-958042

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  12 in total

1.  4,5,7,8,17-Penta-hydr-oxy-14,18-dimethyl-6-methyl-ene-3,10-dioxapenta-cyclo-[9.8.0.0.0.0]nona-dec-14-ene-9,16-dione methanol solvate dihydrate.

Authors:  Chin Hoe Teh; Siew Chin Teoh; Chin Sing Yeap; Kit Lam Chan; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-03-28

2.  Activity of Eurycoma longifolia root extract against Plasmodium falciparum in vitro.

Authors:  Walther H Wernsdorfer; Sabariah Ismail; Kit Lam Chan; Kanungnit Congpuong; Gunther Wernsdorfer
Journal:  Wien Klin Wochenschr       Date:  2009-10       Impact factor: 1.704

3.  In vitro anti-Toxoplasma gondii activity of root extract/fractions of Eurycoma longifolia Jack.

Authors:  Nowroji Kavitha; Rahmah Noordin; Kit-Lam Chan; Sreenivasan Sasidharan
Journal:  BMC Complement Altern Med       Date:  2012-07-10       Impact factor: 3.659

Review 4.  Herbs in exercise and sports.

Authors:  Chee Keong Chen; Ayu Suzailiana Muhamad; Foong Kiew Ooi
Journal:  J Physiol Anthropol       Date:  2012-03-08       Impact factor: 2.867

5.  Effect of selected local medicinal plants on the asexual blood stage of chloroquine resistant Plasmodium falciparum.

Authors:  Mohd Ridzuan Mohd Abd Razak; Adlin Afzan; Rosnani Ali; Nur Fasihah Amir Jalaluddin; Mohd Isa Wasiman; Siti Habsah Shiekh Zahari; Noor Rain Abdullah; Zakiah Ismail
Journal:  BMC Complement Altern Med       Date:  2014-12-15       Impact factor: 3.659

6.  Role of quassinoids as potential antimalarial agents: An in silico approach.

Authors:  Shailima Rampogu
Journal:  Anc Sci Life       Date:  2015 Oct-Dec

7.  First Report of Eurycoma longifolia Jack Root Extract Causing Relaxation of Aortic Rings in Rats.

Authors:  Bae Huey Tee; See Ziau Hoe; Swee Hung Cheah; Sau Kuen Lam
Journal:  Biomed Res Int       Date:  2016-10-09       Impact factor: 3.411

8.  In Vitro Evaluation of the Effects of Eurycoma longifolia Extract on CYP-Mediated Drug Metabolism.

Authors:  Young Min Han; In Sook Kim; Shaheed Ur Rehman; Kevin Choe; Hye Hyun Yoo
Journal:  Evid Based Complement Alternat Med       Date:  2015-07-09       Impact factor: 2.629

9.  NF-κB inhibitors from Eurycoma longifolia.

Authors:  Thi Van Anh Tran; Clemens Malainer; Stefan Schwaiger; Atanas G Atanasov; Elke H Heiss; Verena M Dirsch; Hermann Stuppner
Journal:  J Nat Prod       Date:  2014-01-27       Impact factor: 4.050

10.  Supplementation of Eurycoma longifolia Jack Extract for 6 Weeks Does Not Affect Urinary Testosterone: Epitestosterone Ratio, Liver and Renal Functions in Male Recreational Athletes.

Authors:  Chee Keong Chen; Wan Mohd Zahiruddin Wan Mohamad; Foong Kiew Ooi; Shaiful Bahari Ismail; Mohamad Rusli Abdullah; Annie George
Journal:  Int J Prev Med       Date:  2014-06
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