Literature DB >> 7753843

Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.

R K Singh1, M Gutman, C D Bucana, R Sanchez, N Llansa, I J Fidler.   

Abstract

We investigated the influence of interferons alpha, beta, and gamma (IFN-alpha, -beta, and -gamma) on the production of basic fibroblast growth factor (bFGF) by human renal carcinoma cells. The human renal carcinoma cell metastatic line SN12PM6 was established in culture from a lung metastasis and SN12PM6-resistant cells were selected in vitro for resistance to the antiproliferative effects of IFN-alpha or IFN-beta. IFN-alpha and IFN-beta, but not IFN-gamma, down-regulated the expression of bFGF at the mRNA and protein levels by a mechanism independent of their antiproliferative effects. Down-regulation of bFGF required a long exposure (> 4 days) of cells to low concentrations (> 10 units/ml) of IFN-alpha or IFN-beta. The withdrawal of IFN-alpha or IFN-beta from the medium permitted SN12PM6-resistant cells to resume production of bFGF. The incubation of human bladder, prostate, colon, and breast carcinoma cells with noncytostatic concentrations of IFN-alpha or IFN-beta also produced down-regulation of bFGF production.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7753843      PMCID： PMC41984          DOI： 10.1073/pnas.92.10.4562

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  34 in total

Review 1.  Angiogenic factors.

Authors:  J Folkman; M Klagsbrun
Journal:  Science       Date:  1987-01-23       Impact factor: 47.728

2.  Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor.

Authors:  J A Abraham; A Mergia; J L Whang; A Tumolo; J Friedman; K A Hjerrild; D Gospodarowicz; J C Fiddes
Journal:  Science       Date:  1986-08-01       Impact factor: 47.728

3.  Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

Authors:  Y A Sidky; E C Borden
Journal:  Cancer Res       Date:  1987-10-01       Impact factor: 12.701

4.  Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

Authors:  M C Alley; D A Scudiero; A Monks; M L Hursey; M J Czerwinski; D L Fine; B J Abbott; J G Mayo; R H Shoemaker; M R Boyd
Journal:  Cancer Res       Date:  1988-02-01       Impact factor: 12.701

5.  Kaposi's sarcoma and the acquired immunodeficiency syndrome: treatment with high and low doses of recombinant leukocyte A interferon.

Authors:  F X Real; H F Oettgen; S E Krown
Journal:  J Clin Oncol       Date:  1986-04       Impact factor: 44.544

6.  Basic fibroblast growth factor fused to a signal peptide transforms cells.

Authors:  S Rogelj; R A Weinberg; P Fanning; M Klagsbrun
Journal:  Nature       Date:  1988-01-14       Impact factor: 49.962

7.  A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.

Authors:  A P Feinberg; B Vogelstein
Journal:  Anal Biochem       Date:  1983-07-01       Impact factor: 3.365

8.  Amplification and rearrangement of the Kirsten ras oncogene in virus-transformed BALB/c 3T3 cells during malignant tumor progression.

Authors:  R Radinsky; P M Kraemer; M A Raines; H J Kung; L A Culp
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

9.  Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice.

Authors:  S Naito; A C von Eschenbach; R Giavazzi; I J Fidler
Journal:  Cancer Res       Date:  1986-08       Impact factor: 12.701

Review 10.  Angiogenesis in cancer, vascular, rheumatoid and other disease.

Authors:  J Folkman
Journal:  Nat Med       Date:  1995-01       Impact factor: 53.440
View more
  83 in total

1.  Alpha interferon inhibits human herpesvirus 8 (HHV-8) reactivation in primary effusion lymphoma cells and reduces HHV-8 load in cultured peripheral blood mononuclear cells.

Authors:  P Monini; F Carlini; M Stürzl; P Rimessi; F Superti; M Franco; G Melucci-Vigo; A Cafaro; D Goletti; C Sgadari; S Butto'; P Leone; C Chiozzini; C Barresi; A Tinari; A Bonaccorsi; M R Capobianchi; M Giuliani; A di Carlo; M Andreoni; G Rezza; B Ensoli
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

2.  In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice.

Authors:  C J Bruns; M T Harbison; H Kuniyasu; I Eue; I J Fidler
Journal:  Neoplasia       Date:  1999-04       Impact factor: 5.715

Review 3.  Interferons as antiangiogenic agents.

Authors:  Daniel J Lindner
Journal:  Curr Oncol Rep       Date:  2002-11       Impact factor: 5.075

Review 4.  Giant cell tumor of bone.

Authors:  Alan W Yasko
Journal:  Curr Oncol Rep       Date:  2002-11       Impact factor: 5.075

5.  Interferon therapy and prevention of hepatocellular carcinoma in hepatitis C.

Authors:  Amit G Singal; Jorge A Marrero
Journal:  Dig Dis Sci       Date:  2012-02-22       Impact factor: 3.199

6.  Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice.

Authors:  S J Kim; H Uehara; T Karashima; M Mccarty; N Shih; I J Fidler
Journal:  Neoplasia       Date:  2001 Jan-Feb       Impact factor: 5.715

7.  Systemic IFN-beta gene therapy results in long-term survival in mice with established colorectal liver metastases.

Authors:  H Tada; D J Maron; E A Choi; J Barsoum; H Lei; Q Xie; W Liu; L Ellis; A D Moscioni; J Tazelaar; S Fawell; X Qin; K J Propert; A Davis; D L Fraker; J M Wilson; F R Spitz
Journal:  J Clin Invest       Date:  2001-07       Impact factor: 14.808

Review 8.  Novel molecular pathways in Gorham disease: implications for treatment.

Authors:  Jeroen Hagendoorn; Torunn I Yock; Inne H M Borel Rinkes; Timothy P Padera; David H Ebb
Journal:  Pediatr Blood Cancer       Date:  2013-11-08       Impact factor: 3.167

9.  Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid.

Authors:  Joseph Conlon; Dara L Burdette; Shruti Sharma; Numana Bhat; Mikayla Thompson; Zhaozhao Jiang; Vijay A K Rathinam; Brian Monks; Tengchuan Jin; T Sam Xiao; Stefanie N Vogel; Russell E Vance; Katherine A Fitzgerald
Journal:  J Immunol       Date:  2013-04-12       Impact factor: 5.422

10.  Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice.

Authors:  X Q Qin; N Tao; A Dergay; P Moy; S Fawell; A Davis; J M Wilson; J Barsoum
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-24       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.