Literature DB >> 7753792

Mammary tumor suppression by transforming growth factor beta 1 transgene expression.

D F Pierce1, A E Gorska, A Chytil, K S Meise, D L Page, R J Coffey, H L Moses.   

Abstract

In cell culture, type alpha transforming growth factor (TGF-alpha) stimulates epithelial cell growth, whereas TGF-beta 1 overrides this stimulatory effect and is growth inhibitory. Transgenic mice that overexpress TGF-alpha under control of the mouse mammary tumor virus (MMTV) promoter/enhancer exhibit mammary ductal hyperplasia and stochastic development of mammary carcinomas, a process that can be accelerated by administration of the chemical carcinogen 7,12-dimethylbenz[a]anthracene. MMTV-TGF-beta 1 transgenic mice display mammary ductal hypoplasia and do not develop mammary tumors. We report that in crossbreeding experiments involving the production of mice carrying both the MMTV-TGF-beta 1 and MMTV-TGF-alpha transgenes, there is marked suppression of mammary tumor formation and that MMTV-TGF-beta 1 transgenic mice are resistant to 7,12-dimethylbenz[a]anthracene-induced mammary tumor formation. These data demonstrate that overexpression of TGF-beta 1 in vivo can markedly suppress mammary tumor development.

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Year:  1995        PMID： 7753792      PMCID： PMC41922          DOI： 10.1073/pnas.92.10.4254

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  37 in total

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Journal:  Mol Cell Biol       Date:  1990-09       Impact factor: 4.272

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Authors:  G B Silberstein; C W Daniel
Journal:  Science       Date:  1987-07-17       Impact factor: 47.728

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Journal:  Life Sci       Date:  1986-08-04       Impact factor: 5.037

4.  Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo.

Authors:  E Sinn; W Muller; P Pattengale; I Tepler; R Wallace; P Leder
Journal:  Cell       Date:  1987-05-22       Impact factor: 41.582

5.  Transforming growth factor-beta induces platelet-derived growth factor (PDGF) messenger RNA and PDGF secretion while inhibiting growth in normal human mammary epithelial cells.

Authors:  D A Bronzert; S E Bates; J P Sheridan; R Lindsey; E M Valverius; M R Stampfer; M E Lippman; R B Dickson
Journal:  Mol Endocrinol       Date:  1990-07

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Journal:  Science       Date:  1991-11-22       Impact factor: 47.728

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Authors:  S M Snedeker; C F Brown; R P DiAugustine
Journal:  Proc Natl Acad Sci U S A       Date:  1991-01-01       Impact factor: 11.205

8.  Transforming growth factor-beta 1 overproduction in prostate cancer: effects on growth in vivo and in vitro.

Authors:  M S Steiner; E R Barrack
Journal:  Mol Endocrinol       Date:  1992-01

9.  Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.

Authors:  T Masui; L M Wakefield; J F Lechner; M A LaVeck; M B Sporn; C C Harris
Journal:  Proc Natl Acad Sci U S A       Date:  1986-04       Impact factor: 11.205

10.  Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells.

Authors:  C Knabbe; M E Lippman; L M Wakefield; K C Flanders; A Kasid; R Derynck; R B Dickson
Journal:  Cell       Date:  1987-02-13       Impact factor: 41.582
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  81 in total

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