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Literature DB >> 775091

Polymorphic acetylation of nitrazepam.

Abstract

Nitrazepam is metabolized in part by nitro-reduction to an amine followed by acetylation. This acetylation step has been shown to be under the control of the same genetic polymorphism as sulphamethazine (syn: sulphadimidine).

Entities: Chemical Gene

Mesh：

Substances：
Sulfamethazine
Nitrazepam

Year: 1976 PMID： 775091 PMCID： PMC1013342 DOI： 10.1136/jmg.13.1.17

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

9 in total

1. Polymorphic acetylation of procaine amide in healthy subjects.

Authors: E Karlsson; L Molin
Journal: Acta Med Scand Date: 1975-04

2. HUMAN ACETYLATION POLYMORPHISM.

Authors: D A EVANS; T A WHITE
Journal: J Lab Clin Med Date: 1964-03

3. THE INFLUENCE OF ACETYLATOR PHENOTYPE ON THE EFFECTS OF TREATING DEPRESSION WITH PHENELZINE.

Authors: D A EVANS; K DAVISON; R T PRATT
Journal: Clin Pharmacol Ther Date: 1965 Jul-Aug Impact factor: 6.875

4. Genetic control of isoniazid metabolism in man.

Authors: D A EVANS; K A MANLEY; V A McKUSICK
Journal: Br Med J Date: 1960-08-13

5. The polymorphic acetylation of sulphapyridine in man.

Authors: H Schröder; D A Evans
Journal: J Med Genet Date: 1972-06 Impact factor: 6.318

6. An improved and simplified method of detecting the acetylator phenotype.

Authors: D A Evans
Journal: J Med Genet Date: 1969-12 Impact factor: 6.318

7. [Spectrophotometric determination of 5-phenyl-1,4-benzodiazepine-derivatives and studies on metabolism of nitrazepam. 5. Chemistry and analytics of benzodiazepine-derivatives].

Authors: K H Beyer; W Sadée
Journal: Arzneimittelforschung Date: 1969-12

8. Partial purification and properties of the isoniazid transacetylase in human liver. Its relationship to the acetylation of p-aminosalicylic acid.

Authors: J W Jennne
Journal: J Clin Invest Date: 1965-12 Impact factor: 14.808

9. The polymorphic acetylation of dapsone in man.

Authors: R Gelber; J H Peters; G R Gordon; A J Glazko; L Levy
Journal: Clin Pharmacol Ther Date: 1971 Mar-Apr Impact factor: 6.875

9 in total

16 in total

Review 1. Clinical pharmacokinetics of hypnotics.

Authors: D D Breimer
Journal: Clin Pharmacokinet Date: 1977 Mar-Apr Impact factor: 6.447

2. High incidence of the slow nitrazepam acetylator phenotype in a Nigerian population.

Authors: L C Eze
Journal: Biochem Genet Date: 1987-04 Impact factor: 1.890

3. The relationship between the acetylator and the sparteine hydroxylation polymorphisms.

Authors: D Harmer; D A Evans; L C Eze; M Jolly; E J Whibley
Journal: J Med Genet Date: 1986-04 Impact factor: 6.318

Review 4. Disease and acetylation polymorphism.

Authors: P K Lunde; K Frislid; V Hansteen
Journal: Clin Pharmacokinet Date: 1977 May-Jun Impact factor: 6.447

5. Benzodiazepines: clinical pharmacology and therapeutic use.

Authors: C Bellantuono; V Reggi; G Tognoni; S Garattini
Journal: Drugs Date: 1980-03 Impact factor: 9.546

Review 6. Survey of the human acetylator polymorphism in spontaneous disorders.

Authors: D A Evans
Journal: J Med Genet Date: 1984-08 Impact factor: 6.318

7. Toxicity of nitrazepam in the elderly: a report from the Boston Collaborative Drug Surveillance Program.

Authors: D J Greenblatt; M D Allen
Journal: Br J Clin Pharmacol Date: 1978-05 Impact factor: 4.335

8. Effects of salbutamol on the absorption and disposition of sulphamethoxazole in adult volunteers.

Authors: G I Adebayo; T O Ogundipe
Journal: Eur J Drug Metab Pharmacokinet Date: 1989 Jan-Mar Impact factor: 2.441

9. The association of the slow acetylator phenotype with bladder cancer.

Authors: D A Evans; L C Eze; E J Whibley
Journal: J Med Genet Date: 1983-10 Impact factor: 6.318

10. Objective and subjective assessment of hangover during subacute administration of temazepam and nitrazepam to healthy subjects.

Authors: M J Mattila; K Aranko; M E Mattila; C Strömberg
Journal: Eur J Clin Pharmacol Date: 1984 Impact factor: 2.953