Literature DB >> 7750576

Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells.

Y N Doza1, A Cuenda, G M Thomas, P Cohen, A R Nebreda.   

Abstract

A MAP kinase homologue, termed the reactivating kinase (RK), lies in a signalling pathway which mediates cellular responses to stress. Here we demonstrate that the stress-induced activation of the RK in human KB cells is accompanied by the phosphorylation of Thr-180 and Tyr-182, and that the phosphorylation of both residues is required for the activation of this enzyme.

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Year:  1995        PMID： 7750576     DOI： 10.1016/0014-5793(95)00346-b

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

1.  Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase.

Authors:  Concetta Ambrosino; Gaetane Mace; Stefanie Galban; Cornelius Fritsch; Kristina Vintersten; Emma Black; Myriam Gorospe; Angel R Nebreda
Journal:  Mol Cell Biol       Date:  2003-01       Impact factor: 4.272

2.  Calcium-induced dissociation of CIB1 from ASK1 regulates agonist-induced activation of the p38 MAPK pathway in platelets.

Authors:  Pravin Patel; Meghna U Naik; Kalyan Golla; Noor F Shaik; Ulhas P Naik
Journal:  Biochem J       Date:  2019-10-15       Impact factor: 3.857

3.  Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.

Authors:  A Cuenda; G Alonso; N Morrice; M Jones; R Meier; P Cohen; A R Nebreda
Journal:  EMBO J       Date:  1996-08-15       Impact factor: 11.598

Review 4.  Newer immunosuppressive drugs: their potential role in rheumatoid arthritis therapy.

Authors:  Alexandros A Drosos
Journal:  Drugs       Date:  2002       Impact factor: 9.546

5.  Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38).

Authors:  A Cuenda; P Cohen; V Buée-Scherrer; M Goedert
Journal:  EMBO J       Date:  1997-01-15       Impact factor: 11.598

6.  Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media.

Authors:  Sean D Palacios; Kwang Pak; Alexander Z Rivkin; Ayse G Kayali; Darrell Austen; Christoph Aletsee; Asa Melhus; Nicholas J G Webster; Allen F Ryan
Journal:  Infect Immun       Date:  2004-08       Impact factor: 3.441

7.  p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure.

Authors:  Jan Heinrichsdorff; Tom Luedde; Eusebio Perdiguero; Angel R Nebreda; Manolis Pasparakis
Journal:  EMBO Rep       Date:  2008-08-15       Impact factor: 8.807

8.  Mechanism of p38 MAP kinase activation in vivo.

Authors:  Deborah Brancho; Nobuyuki Tanaka; Anja Jaeschke; Juan-Jose Ventura; Nyaya Kelkar; Yoshinori Tanaka; Masanao Kyuuma; Toshikazu Takeshita; Richard A Flavell; Roger J Davis
Journal:  Genes Dev       Date:  2003-07-31       Impact factor: 11.361

9.  The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

Authors:  R Beyaert; A Cuenda; W Vanden Berghe; S Plaisance; J C Lee; G Haegeman; P Cohen; W Fiers
Journal:  EMBO J       Date:  1996-04-15       Impact factor: 11.598

10.  Centrosomal localization of cyclin E-Cdk2 is required for initiation of DNA synthesis.

Authors:  Rebecca L Ferguson; James L Maller
Journal:  Curr Biol       Date:  2010-04-22       Impact factor: 10.834
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