| Literature DB >> 7750285 |
A F Schlit1, P Grandjean, J Donnez, E Lavenne.
Abstract
Coagulation factors, 11-dehydro-TxB2 (metabolite of TxA2) and 6-keto-PGF1 alpha (metabolite of PGI2) levels in 87 women who were treated for 9 months with oral contraceptives (OC) containing low doses of oestrogens and progestogens (Triquilar, Trinovum or Cilest) were investigated. In plasma, increases in F I, II, VII, VIII-c and 11-dehydro-TxB2 levels, but no modification of 6-keto-PGF1 alpha were observed. In urine, FPA concentration rose, but no change occurred in 11-dehydro-TxB2 and 6-keto-PGF1 alpha levels. No marked difference between the 3 OC preparations were noted. These data, and particularly the large increase of 11-dehydro-TxB2 (p < 0.01) suggest that a hypercoagulable state persists in low dosage OC users.Entities:
Keywords: Belgium; Biology; Blood Coagulation Effects; Clinical Research; Contraception; Contraceptive Methods; Developed Countries; Europe; Examinations And Diagnoses; Family Planning; Hematological Effects; Hemic System; Laboratory Examinations And Diagnoses; Laboratory Procedures; Oral Contraceptives; Oral Contraceptives, Low-dose; Physiology; Research Report; Western Europe
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Year: 1995 PMID： 7750285 DOI： 10.1016/0010-7824(94)00002-e
Source DB: PubMed Journal: Contraception ISSN： 0010-7824 Impact factor: 3.375