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Literature DB >> 7749331

Biochemical properties and biological effects of p53.

Abstract

Over the past year, insights have been made into the biochemistry and biological effects of p53. The high-resolution three-dimensional structure has been determined for the central core and carboxy-terminal domain of the protein, important p53 target genes (such as WAF1) have been identified, and insight has been gained into the relationship between p53-mediated growth arrest and apoptosis.

Entities: Disease Gene

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Year: 1995 PMID： 7749331 DOI： 10.1016/s0959-437x(95)90058-6

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

32 in total

1. Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells.

Authors: M Kanovsky; A Raffo; L Drew; R Rosal; T Do; F K Friedman; P Rubinstein; J Visser; R Robinson; P W Brandt-Rauf; J Michl; R L Fine; M R Pincus
Journal: Proc Natl Acad Sci U S A Date: 2001-10-16 Impact factor: 11.205

2. Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis.

Authors: E Gottlieb; R Haffner; A King; G Asher; P Gruss; P Lonai; M Oren
Journal: EMBO J Date: 1997-03-17 Impact factor: 11.598

3. Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53.

Authors: Y Wu; H Huang; Z Miner; M Kulesz-Martin
Journal: Proc Natl Acad Sci U S A Date: 1997-08-19 Impact factor: 11.205

4. Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter.

Authors: J Bian; Y Sun
Journal: Mol Cell Biol Date: 1997-11 Impact factor: 4.272

Biochemical properties and biological effects of p53.

1. Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells.

2. Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis.

3. Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53.

4. Transcriptional activation by p53 of the human type IV collagenase (gelatinase A or matrix metalloproteinase 2) promoter.

5. p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding.

6. Sp1-mediated transcription of the Werner helicase gene is modulated by Rb and p53.

7. Transrepression of lck gene expression by human T-cell leukemia virus type 1-encoded p40tax.

8. Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response.

9. MEKK1/JNK signaling stabilizes and activates p53.

10. Decreased DNA repair but normal apoptosis in ultraviolet-irradiated skin of p53-transgenic mice.