Literature DB >> 7748267

Increased NMDA receptor and calcium channel activity underlying ethanol withdrawal hyperexcitability.

M A Whittington1, J D Lambert, H J Little.   

Abstract

Withdrawal from chronic ethanol administration results in hyperexcitability. In the hippocampus, evoked bursting activity and spontaneous epileptiform events are seen. The present study investigated the effect of ethanol withdrawal on N-methyl-D-aspartate (NMDA) receptor-mediated postsynaptic potentials and on voltage-gated calcium currents, in mouse hippocampal pyramidal cells. The NMDA receptor-mediated component of synaptic excitation was increased during withdrawal, accompanied by an increase in synaptic activation of calcium spikes. Evidence for a direct effect of ethanol withdrawal on calcium channel function was seen in voltage clamp recordings of isolated, slowly inactivating calcium currents. A synergistic effect of increased NMDA receptor and calcium channel function is therefore suggested to contribute to hyperexcitability during ethanol withdrawal.

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Year:  1995        PMID： 7748267

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN： 0735-0414            Impact factor:   2.826


  16 in total

1.  Repeated exposure to moderate doses of ethanol augments hippocampal glutamate neurotransmission by increasing release.

Authors:  Vladimir Chefer; Jennifer Meis; Grace Wang; Alexander Kuzmin; Georgy Bakalkin; Toni Shippenberg
Journal:  Addict Biol       Date:  2010-12-23       Impact factor: 4.280

2.  Update on the neurobiology of alcohol withdrawal seizures.

Authors:  Michael A Rogawski
Journal:  Epilepsy Curr       Date:  2005 Nov-Dec       Impact factor: 7.500

3.  Altered hippocampal synaptic function in transgenic mice with increased astrocyte expression of CCL2 after withdrawal from chronic alcohol.

Authors:  Jennifer G Bray; Kenneth C Reyes; Amanda J Roberts; Donna L Gruol
Journal:  Neuropharmacology       Date:  2018-02-27       Impact factor: 5.250

Review 4.  The importance of glucocorticoids in alcohol dependence and neurotoxicity.

Authors:  A K Rose; S G Shaw; M A Prendergast; H J Little
Journal:  Alcohol Clin Exp Res       Date:  2010-09-07       Impact factor: 3.455

Review 5.  Homocysteine, Alcoholism, and Its Potential Epigenetic Mechanism.

Authors:  Pradip K Kamat; Carissa J Mallonee; Akash K George; Suresh C Tyagi; Neetu Tyagi
Journal:  Alcohol Clin Exp Res       Date:  2016-11-02       Impact factor: 3.455

6.  Oral administration of glycine and polyamine receptor antagonists blocks ethanol withdrawal seizures.

Authors:  J Kotlinska; S Liljequist
Journal:  Psychopharmacology (Berl)       Date:  1996-10       Impact factor: 4.530

7.  Effects of nitric oxide synthase inhibition in the dorsolateral periaqueductal gray matter on ethanol withdrawal-induced anxiety-like behavior in rats.

Authors:  Vivian Taciany Bonassoli; Ewandro Braz Contardi; Humberto Milani; Rúbia Maria Weffort de Oliveira
Journal:  Psychopharmacology (Berl)       Date:  2013-03-15       Impact factor: 4.530

8.  Nitrendipine prevents the decrease caused by chronic ethanol intake in the maintenance of tetanic long-term potentiation.

Authors:  T L Ripley; H J Little
Journal:  Exp Brain Res       Date:  1995       Impact factor: 1.972

9.  Evaluation of the Anxiolytic Activity of NR-ANX-C (a Polyherbal Formulation) in Ethanol Withdrawal-Induced Anxiety Behavior in Rats.

Authors:  L Mohan; U S C Rao; H N Gopalakrishna; V Nair
Journal:  Evid Based Complement Alternat Med       Date:  2010-09-07       Impact factor: 2.629

10.  Chronic ethanol and withdrawal differentially modulate pre- and postsynaptic function at glutamatergic synapses in rat basolateral amygdala.

Authors:  Anna K Läck; Marvin R Diaz; Ann Chappell; Dustin W DuBois; Brian A McCool
Journal:  J Neurophysiol       Date:  2007-09-26       Impact factor: 2.714
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