Literature DB >> 7748156

Quantitative trait locus analysis of susceptibility to diet-induced atherosclerosis in recombinant inbred mice.

R W Hyman1, S Frank, C H Warden, A Daluiski, R Heller, A J Lusis.   

Abstract

Quantitative trait locus (QTL) analysis is a statistical method that can be applied to identify loci making a significant impact on a phenotype. For the phenotype of susceptibility to diet-induced atherosclerosis in the mouse, we have studied four quantitative traits: area of aortic fatty streaks and serum concentrations of high-density lipoprotein-bound cholesterol (HDL-cholesterol), apolipoprotein A-I, and apolipoprotein A-II (apo A-II). QTL analysis revealed a significant locus on chromosome 1 distal impacting serum apo A-II concentration on a high-fat diet and serum HDL-cholesterol concentration on a chow diet. This locus is presumably Apoa-2, the structural gene for apo A-II. QTL analysis of aortic fatty streaks failed to reveal a significant locus.

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Year:  1994        PMID： 7748156     DOI： 10.1007/BF00566060

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  16 in total

1.  Phenotypic characterization of the Ath-1 gene controlling high density lipoprotein levels and susceptibility to atherosclerosis.

Authors:  R C LeBoeuf; M H Doolittle; A Montcalm; D C Martin; K Reue; A J Lusis
Journal:  J Lipid Res       Date:  1990-01       Impact factor: 5.922

2.  Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.

Authors:  B Paigen; B Y Ishida; J Verstuyft; R B Winters; D Albee
Journal:  Arteriosclerosis       Date:  1990 Mar-Apr

3.  Precipitation methods for quantification of lipoproteins.

Authors:  P S Bachorik; J J Albers
Journal:  Methods Enzymol       Date:  1986       Impact factor: 1.600

4.  Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms.

Authors:  A H Paterson; E S Lander; J D Hewitt; S Peterson; S E Lincoln; S D Tanksley
Journal:  Nature       Date:  1988-10-20       Impact factor: 49.962

5.  Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.

Authors:  B Paigen; D Mitchell; K Reue; A Morrow; A J Lusis; R C LeBoeuf
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

6.  Involvement of the tyrosinase gene in the deposition of cardiac lipofuscin in mice. Association with aortic fatty streak development.

Authors:  J H Qiao; C L Welch; P Z Xie; M C Fishbein; A J Lusis
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

7.  Quantitative assessment of atherosclerotic lesions in mice.

Authors:  B Paigen; A Morrow; P A Holmes; D Mitchell; R A Williams
Journal:  Atherosclerosis       Date:  1987-12       Impact factor: 5.162

8.  Variation in susceptibility to atherosclerosis among inbred strains of mice.

Authors:  B Paigen; A Morrow; C Brandon; D Mitchell; P Holmes
Journal:  Atherosclerosis       Date:  1985-10       Impact factor: 5.162

9.  Genetic control of lipid transport in mice. II. Genes controlling structure of high density lipoproteins.

Authors:  A J Lusis; B A Taylor; R W Wangenstein; R C LeBoeuf
Journal:  J Biol Chem       Date:  1983-04-25       Impact factor: 5.157

10.  Genetic analysis of murine strains C57BL/6J and C3H/HeJ to confirm the map position of Ath-1, a gene determining atherosclerosis susceptibility.

Authors:  B Paigen; D Albee; P A Holmes; D Mitchell
Journal:  Biochem Genet       Date:  1987-08       Impact factor: 1.890
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  4 in total

1.  High-resolution association mapping of atherosclerosis loci in mice.

Authors:  Brian J Bennett; Luz Orozco; Emrah Kostem; Ayca Erbilgin; Marchien Dallinga; Isaac Neuhaus; Bo Guan; Xuping Wang; Eleazar Eskin; Aldons J Lusis
Journal:  Arterioscler Thromb Vasc Biol       Date:  2012-06-21       Impact factor: 8.311

2.  Responsiveness of cardiometabolic-related microbiota to diet is influenced by host genetics.

Authors:  Annalouise O'Connor; Pamela M Quizon; Jody E Albright; Fred T Lin; Brian J Bennett
Journal:  Mamm Genome       Date:  2014-08-27       Impact factor: 2.957

3.  Complex genetic control of HDL levels in mice in response to an atherogenic diet. Coordinate regulation of HDL levels and bile acid metabolism.

Authors:  D Machleder; B Ivandic; C Welch; L Castellani; K Reue; A J Lusis
Journal:  J Clin Invest       Date:  1997-03-15       Impact factor: 14.808

4.  Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice.

Authors:  Jun-Ichi Suto; Misaki Kojima
Journal:  Cholesterol       Date:  2017-05-31
  4 in total

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