Literature DB >> 7747791

Premature centromere division: a possible manifestation of chromosome instability.

K Méhes1, E M Bühler.   

Abstract

Retrospective analysis of "routine" chromosome preparations from 2 patients with Fanconi anemia and 2 others with ataxia-teleangiectasia showed increased chromosome breakage and a tendency to premature centromere division (PCD) with special reference to early separation of the large acrocentric (13-15) chromosomes. The findings suggest that PCD may be a manifestation of chromosome instability related to potential malignancy.

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Year:  1995        PMID： 7747791     DOI： 10.1002/ajmg.1320560117

Source DB:  PubMed          Journal:  Am J Med Genet        ISSN： 0148-7299


  7 in total

1.  Premature chromatid separation is not a useful diagnostic marker for Cornelia de Lange syndrome.

Authors:  Paola Castronovo; Cristina Gervasini; Anna Cereda; Maura Masciadri; Donatella Milani; Silvia Russo; Angelo Selicorni; Lidia Larizza
Journal:  Chromosome Res       Date:  2009-08-19       Impact factor: 5.239

2.  Objective analysis of centromere separation.

Authors:  G Mèhes; A Tàrnok; L Pajor; K Mèhes
Journal:  Hum Genet       Date:  1996-03       Impact factor: 4.132

Review 3.  Chromosomal aneuploidy in the aging brain.

Authors:  Francesca Faggioli; Jan Vijg; Cristina Montagna
Journal:  Mech Ageing Dev       Date:  2011-04-28       Impact factor: 5.432

4.  Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.

Authors:  Lada Zivković; Biljana Spremo-Potparević; Bosiljka Plecas-Solarović; Ninoslav Djelić; Gordana Ocić; Predrag Smiljković; Sandra L Siedlak; Mark A Smith; Vladan Bajić
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-08-30       Impact factor: 6.053

5.  Precocious sister chromatid separation (PSCS) in Cornelia de Lange syndrome.

Authors:  Maninder Kaur; Cheryl DeScipio; Jennifer McCallum; Dinah Yaeger; Marcella Devoto; Laird G Jackson; Nancy B Spinner; Ian D Krantz
Journal:  Am J Med Genet A       Date:  2005-09-15       Impact factor: 2.802

6.  Premature centromere division of the X chromosome in neurons in Alzheimer's disease.

Authors:  Biljana Spremo-Potparević; Lada Zivković; Ninoslav Djelić; Bosiljka Plećas-Solarović; Mark A Smith; Vladan Bajić
Journal:  J Neurochem       Date:  2008-07-09       Impact factor: 5.372

Review 7.  Clinical manifestations of genetic instability overlap one another.

Authors:  Károly Méhes; György Kosztolányi
Journal:  Pathol Oncol Res       Date:  2004-03-18       Impact factor: 3.201
  7 in total

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