| Literature DB >> 7747298 |
S A Shiddo1, H O Akuffo, A A Mohamed, G Huldt, L A Nilsson, O Ouchterlony, R Thorstensson.
Abstract
In an endemic area of Somalia both humoral and cell mediated immunity against Leishmania donovani was demonstrated in 246 inhabitants. In a study of 14 patients with active visceral leishmaniasis, we found that antibodies appear early in infection and that they are then demonstrable for a limited period only. Leishmanin positivity develops later and persists longer, but does not seem to be lifelong. The majority of the immunoreactive individuals were either sero- or leishmanin positive. This finding is in accord with the result obtained in recent experimental studies indicating a regulatory effect exerted on humoral and cell mediated immunity by different T lymphocyte subsets.Entities:
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Year: 1995 PMID： 7747298 DOI： 10.1016/0035-9203(95)90640-1
Source DB: PubMed Journal: Trans R Soc Trop Med Hyg ISSN： 0035-9203 Impact factor: 2.184