| Literature DB >> 7746060 |
S M Berry1, B Lecolier, R S Smith, G Bercau, M P Dombrowski, K S Puder, K Kithier, L Bidat, M P Johnson, D B Cotton.
Abstract
When fetal urinary-tract malformations (UTM) are discovered, management is based on the prediction of postnatal renal function, currently made by fetal urinary biochemistry and sonography. Serum beta 2-microglobulin has been used postnatally to estimate renal function and does not cross the placenta. We investigated the relation between fetal serum beta 2-microglobulin and renal function by comparing 64 unaffected fetuses and 15 fetuses with UTM. A beta 2-microglobulin above a 5.6 mg/L cut-off gave cross-validated sensitivity of 80.0%, specificity of 98.6%, a positive predictive value of 88.9%, and a negative predictive value of 97.1% for our cohort study.Entities:
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Year: 1995 PMID: 7746060 DOI: 10.1016/s0140-6736(95)90928-1
Source DB: PubMed Journal: Lancet ISSN: 0140-6736 Impact factor: 79.321