Literature DB >> 7744262

A critical analysis of the HIV-T4-cell-AIDS hypothesis.

E Papadopulos-Eleopulos1, V F Turner, J M Papadimitriou, D Causer, B Hedland-Thomas, B A Page.   

Abstract

The data generally accepted as proving the HIV theory of AIDS, HIV cytopathy, destruction of T4 lymphocytes, and the relationship between T4 cells, HIV and the acquired immune deficiency clinical syndrome are critically evaluated. It is concluded these data do not prove that HIV preferentially destroys T4 cells or has any cytopathic effects, nor do they demonstrate that T4 cells are preferentially destroyed in AIDS patients, or that T4 cell destruction and HIV are either necessary or sufficient prerequisites for the development of the clinical syndrome.

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Year:  1995        PMID: 7744262     DOI: 10.1007/BF01434999

Source DB:  PubMed          Journal:  Genetica        ISSN: 0016-6707            Impact factor:   1.082


  152 in total

1.  Regulation of cellular and humoral immune responses by T-cell subclasses.

Authors:  H Cantor; E A Boyse
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1977

2.  Separation of functional subsets of human T cells by a monoclonal antibody.

Authors:  E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

3.  Signs and symptoms of "asymptomatic" HIV-1 infection in homosexual men. Multicenter AIDS Cohort Study.

Authors:  D R Hoover; A J Saah; H Bacellar; R Murphy; B Visscher; R Anderson; R A Kaslow
Journal:  J Acquir Immune Defic Syndr (1988)       Date:  1993-01

4.  CD4 defect without HIV in patients with opportunistic infections or Kaposi's sarcoma.

Authors:  M C Sirianni; F Pandolfi; P Verani; E Guerra; G B Rossi; F Aiuti
Journal:  AIDS       Date:  1993-01       Impact factor: 4.177

5.  Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

Authors:  J J Cohen; R C Duke
Journal:  J Immunol       Date:  1984-01       Impact factor: 5.422

Review 6.  Cell death: the significance of apoptosis.

Authors:  A H Wyllie; J F Kerr; A R Currie
Journal:  Int Rev Cytol       Date:  1980

7.  Cytomegalovirus infection and abnormal T-lymphocyte subset ratios in homosexual men.

Authors:  W L Drew; J Mills; J Lèvy; J Dylewski; C Casavant; A J Ammann; H Brodie; T Merigan
Journal:  Ann Intern Med       Date:  1985-07       Impact factor: 25.391

8.  Clinical and epidemiological implications of the Centers for Disease Control/World Health Organization reclassification of AIDS cases.

Authors:  R P Brettle; S M Gore; A G Bird; A J McNeil
Journal:  AIDS       Date:  1993-04       Impact factor: 4.177

9.  The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value.

Authors:  M Levacher; F Hulstaert; S Tallet; S Ullery; J J Pocidalo; B A Bach
Journal:  Clin Exp Immunol       Date:  1992-12       Impact factor: 4.330

Review 10.  Antigens of human T-lymphotropic virus type III/lymphadenopathy-associated virus.

Authors:  M Essex; J Allan; P Kanki; M F McLane; G Malone; L Kitchen; T H Lee
Journal:  Ann Intern Med       Date:  1985-11       Impact factor: 25.391

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  1 in total

Review 1.  Factor VIII, HIV and AIDS in haemophiliacs: an analysis of their relationship.

Authors:  E Papadopulos-Eleopulos; V F Turner; J M Papadimitriou; D Causer
Journal:  Genetica       Date:  1995       Impact factor: 1.082

  1 in total

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