BACKGROUND: Hypocholesterolemia is a risk factor for morbidity and mortality in older people. We have hypothesized that hypocholesterolemia in older people is due to the chronic effect of proinflammatory cytokines on lipoprotein metabolism. METHODS: To test the effects of the chronic administration of interleukin-6 (IL-6) on lipoprotein levels in middle-aged and old rhesus monkeys, five middle-aged and five old rhesus monkeys received a subcutaneous injection of recombinant human IL-6 (15 micrograms/kg) for 28 days. Lipid, apolipoprotein, and albumin levels were measured at 0, 28, and 42 days after injection. RESULTS: Total and HDL cholesterol levels fell by 16 and 23%, respectively, after IL-6 injections. The concentrations of apolipoproteins A1 and B also decreased. The changes in lipoprotein levels were accompanied by a decrease in albumin levels and body weight. Levels of lipids and plasma proteins returned toward normal 2 weeks after injections were stopped. There was no difference in response between middle-aged and older animals. CONCLUSIONS: Chronic IL-6 injections cause acquired hypocholesterolemia, hypoalbuminemia, and weight loss in nonhuman primates. These changes are similar to those seen in older persons with acquired hypocholesterolemia.
BACKGROUND: Hypocholesterolemia is a risk factor for morbidity and mortality in older people. We have hypothesized that hypocholesterolemia in older people is due to the chronic effect of proinflammatory cytokines on lipoprotein metabolism. METHODS: To test the effects of the chronic administration of interleukin-6 (IL-6) on lipoprotein levels in middle-aged and old rhesus monkeys, five middle-aged and five old rhesus monkeys received a subcutaneous injection of recombinant humanIL-6 (15 micrograms/kg) for 28 days. Lipid, apolipoprotein, and albumin levels were measured at 0, 28, and 42 days after injection. RESULTS: Total and HDL cholesterol levels fell by 16 and 23%, respectively, after IL-6 injections. The concentrations of apolipoproteins A1 and B also decreased. The changes in lipoprotein levels were accompanied by a decrease in albumin levels and body weight. Levels of lipids and plasma proteins returned toward normal 2 weeks after injections were stopped. There was no difference in response between middle-aged and older animals. CONCLUSIONS: Chronic IL-6 injections cause acquired hypocholesterolemia, hypoalbuminemia, and weight loss in nonhuman primates. These changes are similar to those seen in older persons with acquired hypocholesterolemia.
Authors: Moniek C M de Goeij; Joris I Rotmans; Xanthe Matthijssen; Dinanda J de Jager; Friedo W Dekker; Nynke Halbesma Journal: Nephron Extra Date: 2015-02-04
Authors: Milica Bozic; Ángeles Álvarez; Carmen de Pablo; Maria-Dolores Sanchez-Niño; Alberto Ortiz; Xavier Dolcet; Mario Encinas; Elvira Fernandez; José Manuel Valdivielso Journal: PLoS One Date: 2015-08-31 Impact factor: 3.240
Authors: Andrew P Koutnik; Angela M Poff; Nathan P Ward; Janine M DeBlasi; Maricel A Soliven; Matthew A Romero; Paul A Roberson; Carl D Fox; Michael D Roberts; Dominic P D'Agostino Journal: J Cachexia Sarcopenia Muscle Date: 2020-04-02 Impact factor: 12.910