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Literature DB >> 7743175

Protein sorting. Pulling in the proteins.

Abstract

Two driving mechanisms, one powered by membrane potential and the other a combination of pulling and trapping, seem to be involved in protein import into mitochondria.

Mesh：

Substances：
Proteins

Year: 1995 PMID： 7743175 DOI： 10.1016/s0960-9822(95)00033-9

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

Keyword Cloud
Cited

26 in total

Review 1. Protein unfolding by mitochondria. The Hsp70 import motor.

Authors: A Matouschek; N Pfanner; W Voos
Journal: EMBO Rep Date: 2000-11 Impact factor: 8.807

2. The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.

Authors: J H Lim; F Martin; B Guiard; N Pfanner; W Voos
Journal: EMBO J Date: 2001-03-01 Impact factor: 11.598

3. Mitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role.

Authors: T Krimmer; J Rassow; W H Kunau; W Voos; N Pfanner
Journal: Mol Cell Biol Date: 2000-08 Impact factor: 4.272

4. The delta psi- and Hsp70/MIM44-dependent reaction cycle driving early steps of protein import into mitochondria.

Authors: C Ungermann; B Guiard; W Neupert; D M Cyr
Journal: EMBO J Date: 1996-02-15 Impact factor: 11.598

5. The mitochondrial protein import motor: dissociation of mitochondrial hsp70 from its membrane anchor requires ATP binding rather than ATP hydrolysis.

Authors: M Horst; W Oppliger; B Feifel; G Schatz; B S Glick
Journal: Protein Sci Date: 1996-04 Impact factor: 6.725

Protein sorting. Pulling in the proteins.

Review 1. Protein unfolding by mitochondria. The Hsp70 import motor.

2. The mitochondrial Hsp70-dependent import system actively unfolds preproteins and shortens the lag phase of translocation.

3. Mitochondrial protein import motor: the ATPase domain of matrix Hsp70 is crucial for binding to Tim44, while the peptide binding domain and the carboxy-terminal segment play a stimulatory role.

4. The delta psi- and Hsp70/MIM44-dependent reaction cycle driving early steps of protein import into mitochondria.

5. The mitochondrial protein import motor: dissociation of mitochondrial hsp70 from its membrane anchor requires ATP binding rather than ATP hydrolysis.

6. Differential requirement for the mitochondrial Hsp70-Tim44 complex in unfolding and translocation of preproteins.

7. Strong precursor-pore interactions constrain models for mitochondrial protein import.

Review 8. Transport of proteins in eukaryotic cells: more questions ahead.

9. Sequential action of two hsp70 complexes during protein import into mitochondria.

10. Unfolding of preproteins upon import into mitochondria.