Literature DB >> 7741742

A three dimensional model for the interaction of MSH with the melanocortin-1 receptor.

P Prusis1, P A Frändberg, R Muceniece, I Kalvinsh, J E Wikberg.   

Abstract

A model for the interaction of the melanocortin-1 (MC1) receptor with MSH peptide has been constructed. The model was built by homology modelling using bacteriorhodopsin as template. A cyclic analogue of MSH could be docked into a binding pocket located between transmembrane (TM) domains 2, 3 and 6 of the receptor. The most significant receptor to ligand interactions occur between D117 in TM3 of receptor with histidine in cyclic MSH-peptide, H260 in TM6 with glutamic in peptide and D121 in TM3 with arginine in peptide. The model finds support from earlier mutagenesis data.

Entities:  

Mesh：

Substances：

Year:  1995        PMID： 7741742     DOI： 10.1006/bbrc.1995.1647

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Interactions of human melanocortin 4 receptor with nonpeptide and peptide agonists.

Authors:  Irina D Pogozheva; Biao-Xin Chai; Andrei L Lomize; Tung M Fong; David H Weinberg; Ravi P Nargund; Michael W Mulholland; Ira Gantz; Henry I Mosberg
Journal:  Biochemistry       Date:  2005-08-30       Impact factor: 3.162

Review 2.  The isoelectric point, a key to understanding a variety of biochemical problems: a minireview.

Authors:  F M A H Schuurmans Stekhoven; M H A G Gorissen; G Flik
Journal:  Fish Physiol Biochem       Date:  2007-08-09       Impact factor: 2.794

3.  Molecular Architecture of G Protein-Coupled Receptors.

Authors:  A Michiel van Rhee; Kenneth A Jacobson
Journal:  Drug Dev Res       Date:  1996-01-01       Impact factor: 4.360

4.  Interaction of Agouti protein with the melanocortin 1 receptor in vitro and in vivo.

Authors:  M M Ollmann; M L Lamoreux; B D Wilson; G S Barsh
Journal:  Genes Dev       Date:  1998-02-01       Impact factor: 11.361

5.  Melanocortin receptor 1 (MC1R) mutations and coat color in pigs.

Authors:  J M Kijas; R Wales; A Törnsten; P Chardon; M Moller; L Andersson
Journal:  Genetics       Date:  1998-11       Impact factor: 4.562

Review 6.  Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor.

Authors:  Victor J Hruby; Minying Cai; James P Cain; Alexander V Mayorov; Matthew M Dedek; Devendra Trivedi
Journal:  Curr Top Med Chem       Date:  2007       Impact factor: 3.295

7.  NMR Insights into the Structure-Function Relationships in the Binding of Melanocortin Analogues to the MC1R Receptor.

Authors:  Maurício Morais; Héctor Zamora-Carreras; Paula D Raposinho; Maria Cristina Oliveira; David Pantoja-Uceda; João D G Correia; M Angeles Jiménez
Journal:  Molecules       Date:  2017-07-15       Impact factor: 4.411
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.