The influence of high fat diet on the fibrinolytic activity.

High fat diet containing 50% fat was given to 28 Chinese healthy volunteers for 3 days. Their mean age was 28.04 years with SD 5.53. Blood glucose, cholesterol, triglyceride (TG) and venous occlusion test (VOT) were determined before and after diet. Tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI) were determined before and after VOT. After high-fat diet, blood glucose and cholesterol increased significantly (p = 0.031, 0.049 respectively), but other parameters did not. TPA increased significantly after VOT either before or after high-fat diet, but such increment was significantly less after high-fat diet (P < 0.05). In conclusion, the immediate effect of short-term high-fat diet included increased plasma levels of glucose and cholesterol, and impaired fibrinolytic response in stress condition.