Literature DB >> 7738786

Effect of increased ppGpp concentration on DNA replication of different replicons in Escherichia coli.

A Herman1, G Wegrzyn.   

Abstract

The plasmids harbouring the relA gene under an inducible promoter allowed us to increase the guanosine 5'-diphosphate-3'-diphosphate (ppGpp) concentration in Escherichia coli cells without any starvation and thus, to directly investigate the effect of ppGpp on DNA replication. We studied all types of replicons which were investigated previously in amino acid-starved bacteria and found that ColE1, oriC, lambda plasmid and pSC101 but not RK2 replicons are sensitive to high ppGpp level. To our knowledge, this paper presents the first direct evidence that replication of most, but not all, replicons is dependent on ppGpp concentration and thus, is under stringent control.

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Year:  1995        PMID： 7738786     DOI： 10.1002/jobm.3620350110

Source DB:  PubMed          Journal:  J Basic Microbiol        ISSN： 0233-111X            Impact factor:   2.281


  5 in total

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2.  Comparative transcription profiling and in-depth characterization of plasmid-based and plasmid-free Escherichia coli expression systems under production conditions.

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4.  Genetic response to metabolic fluctuations: correlation between central carbon metabolism and DNA replication in Escherichia coli.

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Journal:  Microb Cell Fact       Date:  2011-03-31       Impact factor: 5.328

Review 5.  Replicating DNA by cell factories: roles of central carbon metabolism and transcription in the control of DNA replication in microbes, and implications for understanding this process in human cells.

Authors:  Sylwia Barańska; Monika Glinkowska; Anna Herman-Antosiewicz; Monika Maciąg-Dorszyńska; Dariusz Nowicki; Agnieszka Szalewska-Pałasz; Alicja Węgrzyn; Grzegorz Węgrzyn
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  5 in total

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