Literature DB >> 7737481

Defective sterol delta 5(6) desaturase as a cause of azole resistance in Ustilago maydis.

T Joseph-Horne1, N J Manning, D Hollomon, S L Kelly.   

Abstract

Resistance to azole antifungals in Ustilago maydis was associated with a leaky defect in sterol delta 5(6)desaturase. This defect resulted in reduced accumulation of 14 alpha-methylergosta-24(28)-diene-3 beta,6 alpha-diol and an increase in the proportion of 14 alpha-methylfecosterol in treated cells when compared to the parent strain. The results demonstrate the importance of this mechanism in pathogenic fungi.

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Year:  1995        PMID： 7737481     DOI： 10.1111/j.1574-6968.1995.tb07445.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  9 in total

Review 1.  Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

Authors:  T C White; K A Marr; R A Bowden
Journal:  Clin Microbiol Rev       Date:  1998-04       Impact factor: 26.132

2.  Itraconazole resistance in Aspergillus fumigatus.

Authors:  D W Denning; K Venkateswarlu; K L Oakley; M J Anderson; N J Manning; D A Stevens; D W Warnock; S L Kelly
Journal:  Antimicrob Agents Chemother       Date:  1997-06       Impact factor: 5.191

3.  ABC transporters and azole susceptibility in laboratory strains of the wheat pathogen Mycosphaerella graminicola.

Authors:  Lute-Harm Zwiers; Ioannis Stergiopoulos; Johannes G M Van Nistelrooy; Maarten A De Waard
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

4.  The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity.

Authors:  D C Lamb; D E Kelly; T C White; S L Kelly
Journal:  Antimicrob Agents Chemother       Date:  2000-01       Impact factor: 5.191

5.  Reduced accumulation of drug in Candida krusei accounts for itraconazole resistance.

Authors:  K Venkateswarlu; D W Denning; N J Manning; S L Kelly
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

6.  Amphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism and oxidative stress response.

Authors:  Edubiel A Alpizar-Sosa; Nur Raihana Binti Ithnin; Wenbin Wei; Andrew W Pountain; Stefan K Weidt; Anne M Donachie; Ryan Ritchie; Emily A Dickie; Richard J S Burchmore; Paul W Denny; Michael P Barrett
Journal:  PLoS Negl Trop Dis       Date:  2022-09-28

7.  Investigation of the Sterol Composition and Azole Resistance in Field Isolates of Septoria tritici.

Authors:  T Joseph-Horne; D Hollomon; N Manning; S L Kelly
Journal:  Appl Environ Microbiol       Date:  1996-01       Impact factor: 4.792

8.  Cloning of S-adenosyl-L-methionine:C-24-Delta-sterol-methyltransferase (ERG6) from Leishmania donovani and characterization of mRNAs in wild-type and amphotericin B-Resistant promastigotes.

Authors:  Mohammad Pourshafie; Stanislas Morand; Alain Virion; Michaelle Rakotomanga; Corinne Dupuy; Philippe M Loiseau
Journal:  Antimicrob Agents Chemother       Date:  2004-07       Impact factor: 5.191

Review 9.  Non-Target Site Mechanisms of Fungicide Resistance in Crop Pathogens: A Review.

Authors:  Mengjun Hu; Shuning Chen
Journal:  Microorganisms       Date:  2021-02-27
  9 in total

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