Literature DB >> 7737411

Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants.

A Hirasawa1, K Shibata, K Horie, Y Takei, K Obika, T Tanaka, N Muramoto, K Takagaki, J Yano, G Tsujimoto.   

Abstract

We report the cloning and characterization of two isoforms of human alpha 1c-adrenoceptor cDNA (alpha 1c-2, alpha 1c-3). These isoforms are generated by alternative splicing and differ from the clone we previously isolated (alpha 1c-1) in their length and sequences of the C-terminal domain. Tissue distribution of mRNAs showed that these variants co-express with alpha 1c-1 in the human heart, liver, cerebellum and cerebrum. Despite the structural differences, functional experiments in transfected CHO cells showed that the three isoforms have similar ligand binding properties, and all couple with phospholipase C/Ca2+ signaling pathway.

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Year:  1995        PMID： 7737411     DOI： 10.1016/0014-5793(95)00330-c

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

1.  Pharmacological analysis of the novel, selective alpha1-adrenoceptor antagonist, KMD-3213, and its suitability as a tritiated radioligand.

Authors:  S Murata; T Taniguchi; I Muramatsu
Journal:  Br J Pharmacol       Date:  1999-05       Impact factor: 8.739

2.  The effects of SB 216469, an antagonist which discriminates between the alpha 1A-adrenoceptor and the human prostatic alpha 1-adrenoceptor.

Authors:  R Chess-Williams; C R Chapple; F Verfurth; A J Noble; C J Couldwell; M C Michel
Journal:  Br J Pharmacol       Date:  1996-11       Impact factor: 8.739

3.  Alternative splicing generates two isoforms of the beta3-adrenoceptor which are differentially expressed in mouse tissues.

Authors:  B A Evans; M Papaioannou; S Hamilton; R J Summers
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

4.  Evaluation of alpha1-adrenoceptors in the rabbit iris: pharmacological characterization and expression of mRNA.

Authors:  S Nakamura; T Taniguchi; F Suzuki; Y Akagi; I Muramatsu
Journal:  Br J Pharmacol       Date:  1999-07       Impact factor: 8.739

5.  Different subtypes of alpha 1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053.

Authors:  I Marshall; R P Burt; G M Green; M B Hussain; C R Chapple
Journal:  Br J Pharmacol       Date:  1996-09       Impact factor: 8.739

6.  Truncated isoforms inhibit [3H]prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors.

Authors:  F Cogé; S P Guenin; A Renouard-Try; H Rique; C Ouvry; N Fabry; P Beauverger; J P Nicolas; J P Galizzi; J A Boutin; E Canet
Journal:  Biochem J       Date:  1999-10-01       Impact factor: 3.857

7.  Differential modulation of α-1 adrenoceptor subtypes by antidepressants in the rat brain.

Authors:  D Ramakrishna; M N Subhash
Journal:  J Neural Transm (Vienna)       Date:  2010-12-07       Impact factor: 3.575

8.  Splice isoforms of alpha(1a)-adrenoceptor in rabbit.

Authors:  F Suzuki; T Taniguchi; R Takauji; S Murata; I Muramatsu
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

9.  Characterization of alpha 1-adrenoceptors expressed in a novel vascular smooth muscle cell line cloned from p53 knockout mice, P53LMAC01 (AC01) cells.

Authors:  K Ohmi; H Shinoura; Y Nakayama; N Goda; G Tsujimoto
Journal:  Br J Pharmacol       Date:  1999-06       Impact factor: 8.739

10.  Mouse beta 3a- and beta 3b-adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways.

Authors:  Dana S Hutchinson; Tore Bengtsson; Bronwyn A Evans; Roger J Summers
Journal:  Br J Pharmacol       Date:  2002-04       Impact factor: 8.739
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