Literature DB >> 7737339

Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons.

P Molnár1, S L Erdö.   

Abstract

The effects of vinpocetine and phenytoin on voltage-gated Na+ channels were examined on cultured cerebrocortical neurones of the rat using a conventional whole-cell patch-clamp method. Vinpocetine and phenytoin decreased Na+ currents in a concentration-dependent manner, with IC50 values of 44.2 +/- 14.6 and 50.5 +/- 17.4 microM, respectively. Both compounds shifted the voltage dependence of the steady-state inactivation of the channel in the hyperpolarising direction. This pronounced Na+ channel blocking activity may contribute to the neuroprotective and anticonvulsant effects of vinpocetine.

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Year:  1995        PMID： 7737339     DOI： 10.1016/0014-2999(94)00755-v

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  13 in total

1.  Cyclic GTP imitates the potentiating effect of the nootrope vinpocetine on the high-threshold A-current in mollusk neurons.

Authors:  E I Solntseva
Journal:  Neurosci Behav Physiol       Date:  1999 Nov-Dec

2.  Vinpocetine selectively inhibits neurotransmitter release triggered by sodium channel activation.

Authors:  M Sitges; V Nekrassov
Journal:  Neurochem Res       Date:  1999-12       Impact factor: 3.996

Review 3.  An update on vinpocetine: New discoveries and clinical implications.

Authors:  Yi-Shuai Zhang; Jian-Dong Li; Chen Yan
Journal:  Eur J Pharmacol       Date:  2017-11-26       Impact factor: 4.432

4.  The nootropic drug vinpocetine inhibits veratridine-induced [Ca2+]i increase in rat hippocampal CA1 pyramidal cells.

Authors:  T Zelles; L Franklin; I Koncz; B Lendvai; G Zsilla
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

Review 5.  Voltage-gated sodium channels: pharmaceutical targets via anticonvulsants to treat epileptic syndromes.

Authors:  Mena Abdelsayed; Stanislav Sokolov
Journal:  Channels (Austin)       Date:  2013-03-26       Impact factor: 2.581

Review 6.  Vinpocetine for acute ischaemic stroke.

Authors:  D Bereczki; I Fekete
Journal:  Cochrane Database Syst Rev       Date:  2008-01-23

7.  Vinpocetine reduces carrageenan-induced inflammatory hyperalgesia in mice by inhibiting oxidative stress, cytokine production and NF-κB activation in the paw and spinal cord.

Authors:  Kenji W Ruiz-Miyazawa; Ana C Zarpelon; Felipe A Pinho-Ribeiro; Gabriela F Pavão-de-Souza; Rubia Casagrande; Waldiceu A Verri
Journal:  PLoS One       Date:  2015-03-30       Impact factor: 3.240

Review 8.  Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies.

Authors:  Surojit Paul; Eduardo Candelario-Jalil
Journal:  Exp Neurol       Date:  2020-11-02       Impact factor: 5.330

9.  Effects of various antiepileptics used to alleviate neuropathic pain on compound action potential in frog sciatic nerves: comparison with those of local anesthetics.

Authors:  Yuhei Uemura; Tsugumi Fujita; Sena Ohtsubo; Naomi Hirakawa; Yoshiro Sakaguchi; Eiichi Kumamoto
Journal:  Biomed Res Int       Date:  2014-02-24       Impact factor: 3.411

10.  Physiological maturation and drug responses of human induced pluripotent stem cell-derived cortical neuronal networks in long-term culture.

Authors:  A Odawara; H Katoh; N Matsuda; I Suzuki
Journal:  Sci Rep       Date:  2016-05-18       Impact factor: 4.379
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